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Research ArticleArticle

IDENTIFICATION AND ASSAY OF SEROTONIN IN BRAIN

Donald F. Bogdanski, Alfred Pletscher, Bernard B. Brodie and Sidney Udenfriend
Journal of Pharmacology and Experimental Therapeutics May 1956, 117 (1) 82-88;
Donald F. Bogdanski
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Alfred Pletscher
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Bernard B. Brodie
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Sidney Udenfriend
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Abstract

1. A fluorometric method for the determination of serotonin (5-hydroxytryp-tamine) in brain is described. The procedure involves the use of a spectrophoto-fluorometer which can activate and measure emitted fluorescence continuously from 250 to 650 mµ. Serotonin is activated maximally at 295 mµ and emits fluorescent light which shows a maximum at 550 mµ.

2. With this method serotonin has been shown to be a normal constituent of brain.

3. The fluorescent procedure may be applied to the measurement of serotonin in other tissues.

Footnotes

    • Received December 12, 1955.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 117, Issue 1
1 May 1956
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Research ArticleArticle

IDENTIFICATION AND ASSAY OF SEROTONIN IN BRAIN

Donald F. Bogdanski, Alfred Pletscher, Bernard B. Brodie and Sidney Udenfriend
Journal of Pharmacology and Experimental Therapeutics May 1, 1956, 117 (1) 82-88;

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Research ArticleArticle

IDENTIFICATION AND ASSAY OF SEROTONIN IN BRAIN

Donald F. Bogdanski, Alfred Pletscher, Bernard B. Brodie and Sidney Udenfriend
Journal of Pharmacology and Experimental Therapeutics May 1, 1956, 117 (1) 82-88;
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