Abstract
Ajmaline and serpentine have been found to be more active than quinidine in the following tests: (1) refractory period of isolated rabbit atria, (2) auricular fibrillation evoked in dogs by (a) acetylcholine and (b) aconitine, (3) auricular flutter produced in dogs by the injury-stimulation procedure and (4) hydrocarbon -epinephrine- induced ventricular arrhythmias in anesthetized dogs.
When the effects of these drugs were compared on the electrocardiograms of cats, ajmaline and serpentine were found to cause greater prolongation of refractory period and conduction time than quinidine.
Footnotes
- Received December 6, 1955.
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