Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

STUDIES ON THE PHARMACOLOGY OF TETRAETHYLPYROPHOSPHATE

Edmund F. Murtha, Bernard P. McNamara, Lawrence J. Edberg, A. Dorothy Bergner and J. Henry Wills
Journal of Pharmacology and Experimental Therapeutics November 1955, 115 (3) 291-299;
Edmund F. Murtha
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bernard P. McNamara
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lawrence J. Edberg
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Dorothy Bergner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Henry Wills
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

An attempt has been made to relate the effects produced by TEPP on the mechanical response of the gastrocnemius-soleus-tibialis anticus mnuscle group and on the spike potential of the sciatic nerve of the cat with changes in cholinesterase activity in these two sites. When nerve conduction and muscular response of one leg had been abolished, the enzymatic activities in the corresponding nerve and muscle of the opposite leg were greatly reduced but still detectable. After nerve conduction and muscular response had returned in the stimulated leg, the cholinesterase activities in this nerve and muscle were at the levels found in the opposite leg at the time at which function was absent.

It is possible that TEPP, when used as a tool in pharmacological or physiological research, produces effects on neuromuscular function which are not related necessarily to inhibition of cholinesterase. Therefore, this compound should be employed in this capacity with certain reservations.

Footnotes

    • Received June 25, 1955.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 115, Issue 3
1 Nov 1955
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
STUDIES ON THE PHARMACOLOGY OF TETRAETHYLPYROPHOSPHATE
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

STUDIES ON THE PHARMACOLOGY OF TETRAETHYLPYROPHOSPHATE

Edmund F. Murtha, Bernard P. McNamara, Lawrence J. Edberg, A. Dorothy Bergner and J. Henry Wills
Journal of Pharmacology and Experimental Therapeutics November 1, 1955, 115 (3) 291-299;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

STUDIES ON THE PHARMACOLOGY OF TETRAETHYLPYROPHOSPHATE

Edmund F. Murtha, Bernard P. McNamara, Lawrence J. Edberg, A. Dorothy Bergner and J. Henry Wills
Journal of Pharmacology and Experimental Therapeutics November 1, 1955, 115 (3) 291-299;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Pharmacological Characterization of Nicotine-Induced Seizures in Mice
  • Streptococcus pneumoniae Pneumonia in Mice: Optimal Amoxicillin Dosing Predicted from a Pharmacokinetic-Pharmacodynamic Model
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics