Abstract
Specific methods for the determination of hutabarbital in plasma and urine are described.
Butabarbital disappears from the plasma of dogs at a rate of about 6 per cent per hour. This rate, which is intermediate between those for barbital and pentobarbital, supports the concept that the length of depressant action of a dialkylbarbiturate depends to a considerable extent upon the duration of its sojourn in the body.
Unchanged butabarhital equivalent to 3-5 per cent of the dose could be detected in the urine.
A metabolite which was proved to be 5-ethyl, 5(1-methyl, 2-carboxyethyl)-barbituric acid was isolated from urine. Two dogs excreted this compound in amounts corresponding to 28 and 35 per cent of a dose of butabarbital.
Butabarbital causes increased amounts of glucuronides to appear in urine.
Footnotes
- Received June 20, 1955.
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