Abstract
The oral administration of 5 mgm. of fluorine as sodium fluoride or stannous fluoride resulted in hypotension. Sodium fluoride containing 1 mgm. of fluorine, the amount orally ingested daily by the average person from a communal water supply containing 1.0 ppm, did not elicit a hypotensive response. In the conditions where sufficient fluorine was administered to alter the blood pressure, there were changes in the heart rate, pulse pressure and blood flow as would be expected with a hypotensive agent. Stannous fluoride elicited also a decline in the rectal and gastrocnemius muscle temperatures.
We wish to acknowledge the technical assistance of Patricia A. Doane and James C. Walker during these studies.
Footnotes
- Received October 2, 1954.
- © 1955, by The Williams & Wilkins Company
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