Abstract
Single intravenous injections of a basic cyanine dye into dogs, in amounts ranging from 1.25 to 12.5 micromoles/kgm., produced a marked and prolonged inhibition of the renal tubular excretion of N'-methylnicotinamide (NMN). The renal excretion characteristics of creatinine, p-aminohippurate and glucose were not altered under these conditions. In an earlier study, larger doses of the cyanine (25 or more micromoles/kgm.) frequently produced renal tubular injury with nonspecific, generalized, renal functional impairment.
Speculation concerning the mechanism of the inhibition of NMN excretion, and its significance for further studies of the renal tubular transport system involved, are discussed.
Footnotes
- Received September 16, 1954.
- © 1955, by The Williams & Wilkins Company
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