Abstract
Benzoic acid, with an intraperitoneal dose of 1.86 mM/kgm., will result in a significant depletion of adrenal ascorbic acid in the rat measured two hours later. Substitution of an o-hydroxyl group in the benzoic acid ring enhances the activity in equimolar doses. Substitution of a halogen in the ortho position removes the activity. However, substitution of a halogen in meta or para positions enhances the activity in doses equimolar to benzoic acid. An exception to this is fluorine which appears not to affect significantly the activity of benzoic acid when substituted in the meta or para positions.
Some possible explanations of the structure-function relationship are discussed, but a satisfactory explanation seems not to he available as yet.
Footnotes
- Received August 13, 1954.
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