Abstract
A method is described for the estimation of pentobarbital and other oxy-barbiturates in biological fluids and tissues.
Pentobarbital is almost entirely metabolized in man. A major metabolic product is d-5-ethyl-5-(3-hydroxy-1-methylbutyl) barbituric acid.
Unlike thiopental, pentobarbital is not extensively localized in body fat. This explains, in large part, why pentobarbital is not as short acting an anesthetic as thiopental.
In man pentobarbital is metabolized more slowly than thiopental, whereas in the dog the reverse is true. This suggests that the two compounds are metabolized by different biochemical mechanisms.
Footnotes
- Received March 14, 1953.
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