Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

THE FATE OF BENZAZOLINE (PRISCOLINE) IN DOG AND MAN AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL

Bernard B. Brodie, Lewis Aronow and Julius Axelrod
Journal of Pharmacology and Experimental Therapeutics October 1952, 106 (2) 200-207;
Bernard B. Brodie
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lewis Aronow
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julius Axelrod
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

1. A method is described for the estimation of Priscoline in biological fluids and tissues.

2. Priscoline administered to man and dog has a biologic half life of about two hours and is excreted in urine essentially unchanged.

3. The renal elimination of Priscoline is brought about by a tubular secretory transport mechanism in addition to glomerular filtration.

4. In contrast to Dibenamine, Priscoline is not localized in adipose tissues.

5. In the dog, reversal of the pressor response to a test dose of epinephrine (2.5 microgm. per kgm.) occurs at plasma levels of Priscoline in the approximate range of 2 mgm. per liter and partial blocking at levels in the approximate range of 0.3 mgm. to 2 mgm. per liter.

Footnotes

    • Received June 7, 1952.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 106, Issue 2
1 Oct 1952
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
THE FATE OF BENZAZOLINE (PRISCOLINE) IN DOG AND MAN AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

THE FATE OF BENZAZOLINE (PRISCOLINE) IN DOG AND MAN AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL

Bernard B. Brodie, Lewis Aronow and Julius Axelrod
Journal of Pharmacology and Experimental Therapeutics October 1, 1952, 106 (2) 200-207;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

THE FATE OF BENZAZOLINE (PRISCOLINE) IN DOG AND MAN AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL

Bernard B. Brodie, Lewis Aronow and Julius Axelrod
Journal of Pharmacology and Experimental Therapeutics October 1, 1952, 106 (2) 200-207;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Allosteric Modulation and Accelerated Resensitization of Human P2X3 Receptors by Cibacron Blue
  • Meeting Report for the ASPET–Ray Fuller Symposium: Cellular Mechanisms and Novel Strategies for Pain Control
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics