Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

SOME ACTIONS OF PROCAINE AND RELATED COMPOUNDS ON THE DOG'S AURICLE AND A-V CONNECTIONS

Barbara B. Brown and George H. Acheson
Journal of Pharmacology and Experimental Therapeutics December 1951, 103 (4) 269-279;
Barbara B. Brown
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
George H. Acheson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The exposed auricle of the anesthetized dog was stimulated at its tip. Electrograms were recorded from distant auricular spots.

1. Auricular conduction velocity was studied as a function of auricular rate. Vagal stimulation increases it principally at high rates, whereas sympathetic stimulation increases it at all rates. Procaine (8 mgm. per kgm.) decreases it at all rates, whereas diethylaminoethanol (DEAE) (32 mgm. per kgm.) and diethylaminoethyl 2,4-dichlorobenzoate (DCB) (8 mgm. per kgm.) decrease it principally at high rates.

2. The threshold voltage was determined at different rates of stimulation of the auricle. Section of the vagi alone or of the sympathetics alone or stimulation of either of these nerves decreases threshold at all auricular rates. Section of both nerves increases the thresholds. Procaine increases thresholds only at high auricular rates, whereas DEAE and DCB increase them at all rates.

3. The maximal rate at which the auricle will respond when driven by impulses conducted from a distant stimulated auricular site is increased by vagal or sympathetic stimulation and decreased by procaine, DEAE, and DCB.

4. The ventricular rate was studied as a function of auricular rate. Sympathetic tonic discharge seems to predominate over vagal. Procaine improves the ability of the ventricle to follow the auricle in the innervated heart but impairs it after decentralization; and procaine blocks the effects of vagal or sympathetic stimulation. DEAE and DCB impair the ability of the ventricle to follow the auricle in innervated or decentralized hearts and do not effectively block the effects of stimulating the nerves.

Footnotes

    • Received July 23, 1951.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 103, Issue 4
1 Dec 1951
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
SOME ACTIONS OF PROCAINE AND RELATED COMPOUNDS ON THE DOG'S AURICLE AND A-V CONNECTIONS
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

SOME ACTIONS OF PROCAINE AND RELATED COMPOUNDS ON THE DOG'S AURICLE AND A-V CONNECTIONS

Barbara B. Brown and George H. Acheson
Journal of Pharmacology and Experimental Therapeutics December 1, 1951, 103 (4) 269-279;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

SOME ACTIONS OF PROCAINE AND RELATED COMPOUNDS ON THE DOG'S AURICLE AND A-V CONNECTIONS

Barbara B. Brown and George H. Acheson
Journal of Pharmacology and Experimental Therapeutics December 1, 1951, 103 (4) 269-279;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Is Hydroxylamine-Induced Cytotoxicity a Valid Marker for Hypersensitivity Reactions to Sulfamethoxazole in Human Immunodeficiency Virus-Infected Individuals?
  • Pharmacodynamics of Immunosuppression by Mycophenolic Acid: Inhibition of Both Lymphocyte Proliferation and Activation Correlates with Pharmacokinetics
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics