Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

PARASYMPATHOMIMETIC EFFECTS OF THE ETHYLAL OF γ-TRIMETHYLAMMONIUMPROPANEDIOL IODIDE (F2268)

E. A. Carr Jr. and D. S. Riggs
Journal of Pharmacology and Experimental Therapeutics August 1951, 102 (4) 272-285;
E. A. Carr Jr.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. S. Riggs
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

1. The ethylal of γ-trimethylammoniumpropanediol iodide (F2268) has a pressor action in atropinized intact and spinal cats. A dose of 1 to 10 mgm./kgm. of F2268 is usually required to produce this action, which is due to ganglionic stimulation.

2. When a dose of 6 mgm./kgm. of F2268 is given repeatedly to atropinized spinal cats, two effects are seen. Initially a stepwise increase in the pressor response to successive doses occurs. Later an interfering action, which probably represents ganglionic block, becomes evident.

3. When a dose of 6 mgm./kgm. of F2268 is given repeatedly to atropinized spinal cats, a depressor action can be observed after the pressor action has been abolished by tetraethylammonium. The depressor action remains constant with repeated doses.

4. When repeated doses of 1 mgm./kgm. of acetylcholine bromide and 6 mgm./kgm. of F2268 are given alternately to atropinized spinal cats the pressor response to acetylcholine shows an initial stepwise increase and a later decrease, while the pressor response to F2268 shows only a steady decrease.

5. In unatropinized animals, F2268 exerts typical muscarinic actions on heart rate, blood pressure, secretion of salivary, lacrimal and bronchial glands, and intestinal smooth muscle. In doses of 10 microgm. or more, F2268 is more potent than methacholine chloride in lowering the blood pressure, slowing the heart rate, and causing cardiac arrhythmias. F2268 exerts a more prolonged muscarinic action on the heart than does methacholine.

Footnotes

    • Received May 21, 1951.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 102, Issue 4
1 Aug 1951
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
PARASYMPATHOMIMETIC EFFECTS OF THE ETHYLAL OF γ-TRIMETHYLAMMONIUMPROPANEDIOL IODIDE (F2268)
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

PARASYMPATHOMIMETIC EFFECTS OF THE ETHYLAL OF γ-TRIMETHYLAMMONIUMPROPANEDIOL IODIDE (F2268)

E. A. Carr and D. S. Riggs
Journal of Pharmacology and Experimental Therapeutics August 1, 1951, 102 (4) 272-285;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

PARASYMPATHOMIMETIC EFFECTS OF THE ETHYLAL OF γ-TRIMETHYLAMMONIUMPROPANEDIOL IODIDE (F2268)

E. A. Carr and D. S. Riggs
Journal of Pharmacology and Experimental Therapeutics August 1, 1951, 102 (4) 272-285;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • PST3093 Stimulates SERCA2a and Improves Cardiac Function
  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Ethnic Differences in N-Glucuronidation of Nicotine and Cotinine
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics