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TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy
Takashi Ishikawa, Hiroe Hara, Ayumi Kawano, Kimio Tohyama, Yuichi Kajita, Yuhei Miyanohana, Tatsuki Koike and Haruhide Kimura

Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 193-204; DOI: https://doi.org/10.1124/jpet.122.001449
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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease
Jenny V. Tobin, Daniel P. Zimmer, Courtney Shea, Peter Germano, Sylvie G. Bernier, Guang Liu, Kim Long, Joy Miyashiro, Sheila Ranganath, Sarah Jacobson, Kim Tang, G-Yoon Jamie Im, James Sheppeck, Joel D. Moore, Kristine Sykes, James Wakefield, Renee Sarno, Ali R. Banijamali, Albert T. Profy, G. Todd Milne, Mark G. Currie and Jaime L. Masferrer

Journal of Pharmacology and Experimental Therapeutics June 2018, 365 (3) 664-675; DOI: https://doi.org/10.1124/jpet.117.247429
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Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System
N. Tsamandouras, T. Kostrzewski, C. L. Stokes, L. G. Griffith, D. J. Hughes and M. Cirit

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 95-105; DOI: https://doi.org/10.1124/jpet.116.237495
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PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway
Brigitte Grouix, Francois Sarra-Bournet, Martin Leduc, Jean-Christophe Simard, Kathy Hince, Lilianne Geerts, Alexandra Blais, Liette Gervais, Alexandre Laverdure, Alexandra Felton, Jonathan Richard, Jugurtha Ouboudinar, William Gagnon, François A. Leblond, Pierre Laurin and Lyne Gagnon

Journal of Pharmacology and Experimental Therapeutics October 2018, 367 (1) 71-81; DOI: https://doi.org/10.1124/jpet.118.250068
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Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N-Acetylgalactosamine–Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans
Vivaswath S. Ayyar, Dawei Song, Songmao Zheng, Thomas Carpenter and Donald L. Heald

Journal of Pharmacology and Experimental Therapeutics November 2021, 379 (2) 134-146; DOI: https://doi.org/10.1124/jpet.121.000805
Open Access
Icariin Delays Brain Aging in Senescence-Accelerated Mouse Prone 8 (SAMP8) Model via Inhibiting Autophagy
Fa-Ju Chen, Bo Liu, Qin Wu, Jie Liu, Yun-Yan Xu, Shao-Yu Zhou and Jing-Shan Shi

Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 121-128; DOI: https://doi.org/10.1124/jpet.118.253310
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Apparent Affinity Estimates and Reversal of the Effects of Synthetic Cannabinoids AM-2201, CP-47,497, JWH-122, and JWH-250 by Rimonabant in Rhesus Monkeys
Lenka Hruba and Lance R. McMahon

Journal of Pharmacology and Experimental Therapeutics August 2017, 362 (2) 278-286; DOI: https://doi.org/10.1124/jpet.117.240572
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Anticancer Activity of Natural and Synthetic Capsaicin Analogs
Jamie R. Friedman, Nicholas A. Nolan, Kathleen C. Brown, Sarah L. Miles, Austin T. Akers, Kate W. Colclough, Jessica M. Seidler, John M. Rimoldi, Monica A. Valentovic and Piyali Dasgupta

Journal of Pharmacology and Experimental Therapeutics March 2018, 364 (3) 462-473; DOI: https://doi.org/10.1124/jpet.117.243691
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Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia
Elizabeth Brigham, Tom Johnston, Carl Brown, Jonathon Holt, Susan Fox, Michael Hill, Patrick Howson, Jonathan Brotchie and Jack Nguyen

Journal of Pharmacology and Experimental Therapeutics August 7, 2018, jpet.118.247650; DOI: https://doi.org/10.1124/jpet.118.247650
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ASP7266, a Novel Antibody against Human Thymic Stromal Lymphopoietin Receptor for the Treatment of Allergic Diseases
Mako Numazaki, Masaki Abe, Kaori Hanaoka, Emiko Imamura, Masashi Maeda, Akihiko Kimura, Jun Miyanohara, Tetsu Saito, Kazunori Arai, Hiroshi Suzuki and Yuji Saita

Journal of Pharmacology and Experimental Therapeutics January 2022, 380 (1) 26-33; DOI: https://doi.org/10.1124/jpet.121.000686

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