Most-Read Articles during September 2009 -- updated monthly.

Most-read rankings are recalculated at the beginning of the month and are based on full-text and pdf views.

  1. Article:
    • Amber L. Pond,
    • Howard W. Chambers,
    • Cody P. Coyne,
    • and Janice E. Chambers
    Purification of Two Rat Hepatic Proteins with A-Esterase Activity Toward Chlorpyrifos-Oxon and Paraoxon J Pharmacol Exp Ther September 1, 1998 286:1404-1411
  2. CELLULAR AND MOLECULAR:
    • Craig E. Crosson,
    • Phillip W. Yates,
    • Aruna N. Bhat,
    • Yurii V. Mukhin,
    • and Shahid Husain
    Evidence for Multiple P2Y Receptors in Trabecular Meshwork Cells J Pharmacol Exp Ther May 2004 309:484-489; published ahead of print January 23, 2004, doi:10.1124/jpet.103.060319
  3. Article:
    • Seddigheh Razani-Boroujerdi,
    • Bruce Edwards,
    • and Mohan L. Sopori
    Lead Stimulates Lymphocyte Proliferation Through Enhanced T Cell-B Cell Interaction J Pharmacol Exp Ther February 1, 1999 288:714-719
  4. Article:
    • Steven L. Parker,
    • Michael S. Parker,
    • Trevor Sweatman,
    • and William R. Crowley
    Characterization of G Protein and Phospholipase C-Coupled Agonist Binding to the Y1 Neuropeptide Y Receptor in Rat Brain: Sensitivity to G Protein Activators and Inhibitors and to Inhibitors of Phospholipase C , J Pharmacol Exp Ther July 1, 1998 286:382-391
  5. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:
    • Abdul E. Mutlib,
    • John Shockcor,
    • Robert Espina,
    • Nilsa Graciani,
    • Alicia Du,
    • and Liang-Shang Gan
    Disposition of Glutathione Conjugates in Rats by a Novel Glutamic Acid Pathway: Characterization of Unique Peptide Conjugates by Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/NMR J Pharmacol Exp Ther August 1, 2000 294:735-745
  6. Inflammation, Immunopharmacology, and Asthma:
    • Laura M Kreckler,
    • Elizabeth Gizewski,
    • Tina C Wan,
    • and John A. Auchampach
    Adenosine suppresses LPS-induced TNF-α production by murine macrophages through a protein kinase A- and Epac-independent signaling pathway J Pharmacol Exp Ther ; published ahead of print September 11, 2009, doi:10.1124/jpet.109.157651
  7. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:
    • Cathaleen Shu,
    • Hong Shen,
    • Nathan S. Teuscher,
    • Philip J. Lorenzi,
    • Richard F. Keep,
    • and David E. Smith
    Role of PEPT2 in Peptide/Mimetic Trafficking at the Blood-Cerebrospinal Fluid Barrier: Studies in Rat Choroid Plexus Epithelial Cells in Primary Culture J Pharmacol Exp Ther June 1, 2002 301:820-829; doi:10.1124/jpet.301.3.820
  8. PERSPECTIVES IN PHARMACOLOGY:
    • Ronald J. Tallarida
    Drug Synergism: Its Detection and Applications J Pharmacol Exp Ther September 1, 2001 298:865-872
  9. NEUROPHARMACOLOGY:
    • Thomas M. Tzschentke,
    • Thomas Christoph,
    • Babette Kögel,
    • Klaus Schiene,
    • Hagen-Heinrich Hennies,
    • Werner Englberger,
    • Michael Haurand,
    • Ulrich Jahnel,
    • Thomas I. F. H. Cremers,
    • Elmar Friderichs,
    • and Jean De Vry
    (–)-(1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol Hydrochloride (Tapentadol HCl): a Novel μ-Opioid Receptor Agonist/Norepinephrine Reuptake Inhibitor with Broad-Spectrum Analgesic Properties J Pharmacol Exp Ther October 2007 323:265-276; published ahead of print July 26, 2007, doi:10.1124/jpet.107.126052
  10. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:
    • Vijayakrishna K. Gadi,
    • Sherrie D. Alexander,
    • William R. Waud,
    • Paula W. Allan,
    • William B. Parker,
    • and Eric J. Sorscher
    A Long-Acting Suicide Gene Toxin, 6-Methylpurine, Inhibits Slow Growing Tumors after a Single Administration J Pharmacol Exp Ther March 1, 2003 304:1280-1284; published ahead of print December 13, 2002, doi:10.1124/jpet.102.044743
  11. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:
    • L. Illum,
    • P. Watts,
    • A. N. Fisher,
    • M. Hinchcliffe,
    • H. Norbury,
    • I. Jabbal-Gill,
    • R. Nankervis,
    • and S. S. Davis
    Intranasal Delivery of Morphine J Pharmacol Exp Ther April 1, 2002 301:391-400; doi:10.1124/jpet.301.1.391
  12. THE 1998 ASPET OTTO KRAYER AWARD LECTURE:
    • Theodore A. Slotkin
    Fetal Nicotine or Cocaine Exposure: Which One is Worse? J Pharmacol Exp Ther June 1, 1998 285:931-945
  13. Article:
    • Ioan Puscas,
    • Marcela Coltau,
    • Michael Baican,
    • and Gabriela Domuta
    Omeprazole Has a Dual Mechanism of Action: It Inhibits Both H+K+ATPase and Gastric Mucosa Carbonic Anhydrase Enzyme in Humans (In Vitro and In Vivo Experiments) J Pharmacol Exp Ther August 1, 1999 290:530-534
  14. ENDOCRINE AND DIABETES:
    • Leo Thomas,
    • Matthias Eckhardt,
    • Elke Langkopf,
    • Moh Tadayyon,
    • Frank Himmelsbach,
    • and Michael Mark
    (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior Potency and Longer Duration of Action Compared with Other Dipeptidyl Peptidase-4 Inhibitors J Pharmacol Exp Ther April 2008 325:175-182; published ahead of print January 25, 2008, doi:10.1124/jpet.107.135723
  15. PERSPECTIVES IN PHARMACOLOGY:
    • Amit Arora and
    • Eric M. Scholar
    Role of Tyrosine Kinase Inhibitors in Cancer Therapy J Pharmacol Exp Ther December 2005 315:971-979; published ahead of print July 7, 2005, doi:10.1124/jpet.105.084145
  16. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:
    • Robert P. Hanzlik,
    • Stephen C. Fowler,
    • and Daniel H. Fisher
    Relative Bioavailability of Calcium from Calcium Formate, Calcium Citrate, and Calcium Carbonate J Pharmacol Exp Ther June 2005 313:1217-1222; published ahead of print February 25, 2005, doi:10.1124/jpet.104.081893
  17. INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:
    • Sylvia Braselmann,
    • Vanessa Taylor,
    • Haoran Zhao,
    • Su Wang,
    • Catherine Sylvain,
    • Muhammad Baluom,
    • Kunbin Qu,
    • Ellen Herlaar,
    • Angela Lau,
    • Chi Young,
    • Brian R. Wong,
    • Scott Lovell,
    • Thomas Sun,
    • Gary Park,
    • Ankush Argade,
    • Stipo Jurcevic,
    • Polly Pine,
    • Rajinder Singh,
    • Elliott B. Grossbard,
    • Donald G. Payan,
    • and Esteban S. Masuda
    R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation J Pharmacol Exp Ther December 2006 319:998-1008; doi:10.1124/jpet.106.109058
  18. PERSPECTIVES IN PHARMACOLOGY:
    • Jonathan D. Urban,
    • William P. Clarke,
    • Mark von Zastrow,
    • David E. Nichols,
    • Brian Kobilka,
    • Harel Weinstein,
    • Jonathan A. Javitch,
    • Bryan L. Roth,
    • Arthur Christopoulos,
    • Patrick M. Sexton,
    • Keith J. Miller,
    • Michael Spedding,
    • and Richard B. Mailman
    Functional Selectivity and Classical Concepts of Quantitative Pharmacology J Pharmacol Exp Ther January 2007 320:1-13; published ahead of print June 27, 2006, doi:10.1124/jpet.106.104463
  19. NEUROPHARMACOLOGY:
    • Aynun N. Begum,
    • Mychica R. Jones,
    • Giselle P. Lim,
    • Takashi Morihara,
    • Peter Kim,
    • Dennis D. Heath,
    • Cheryl L. Rock,
    • Mila A. Pruitt,
    • Fusheng Yang,
    • Beverly Hudspeth,
    • Shuxin Hu,
    • Kym F. Faull,
    • Bruce Teter,
    • Greg M. Cole,
    • and Sally A. Frautschy
    Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease J Pharmacol Exp Ther July 2008 326:196-208; published ahead of print April 16, 2008, doi:10.1124/jpet.108.137455
  20. PERSPECTIVES IN PHARMACOLOGY:
    • Sabzali Javadov,
    • Morris Karmazyn,
    • and Nelson Escobales
    Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases J Pharmacol Exp Ther September 2009 330:670-678; published ahead of print June 9, 2009, doi:10.1124/jpet.109.153213
  21. Endocrine and Diabetes:
    • Komal Sodhi,
    • Kazuyoshi Inoue,
    • Katherine Gotlinger,
    • Martina Canestraro,
    • Luca Vanella,
    • Dong Hyun Kim,
    • Vijay L. Manthati,
    • Sreenivasulu Reddy Koduru,
    • John R. Falck,
    • Michal L. Schwartzman,
    • and Nader G. Abraham
    EET Agonist Rescues the Metabolic Syndrome Phenotype of HO-2 Null Mice J Pharmacol Exp Ther ; published ahead of print August 28, 2009, doi:10.1124/jpet.109.157545
  22. BEHAVIORAL PHARMACOLOGY:
    • S. G. Kinsey,
    • J. Z. Long,
    • S. T. O'Neal,
    • R. A. Abdullah,
    • J. L. Poklis,
    • D. L. Boger,
    • B. F. Cravatt,
    • and A. H. Lichtman
    Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain J Pharmacol Exp Ther September 2009 330:902-910; published ahead of print June 5, 2009, doi:10.1124/jpet.109.155465
  23. Neuropharmacology:
    • Matthew J Fell,
    • Kenneth W Perry,
    • Julie F Falcone,
    • Bryan G Johnson,
    • Vanessa N Barth,
    • Karen S Rash,
    • Virginia L Lucaites,
    • Penny G Threlkeld,
    • James A Monn,
    • David McKinize,
    • Gerard J Marek,
    • Kjell A Svensson,
    • and David L. Nelson
    In vitro and in vivo evidence for a lack of interaction with Dopamine D2 receptors by the mGlu2/3 receptor agonists LY354740 and LY379268 J Pharmacol Exp Ther ; published ahead of print September 15, 2009, doi:10.1124/jpet.109.160598
  24. NEUROPHARMACOLOGY:
    • Darlene C. Deecher,
    • Chad E. Beyer,
    • Grace Johnston,
    • Jenifer Bray,
    • S. Shah,
    • M. Abou-Gharbia,
    • and Terrance H. Andree
    Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor J Pharmacol Exp Ther August 2006 318:657-665; published ahead of print May 4, 2006, doi:10.1124/jpet.106.103382
  25. Cellular and Molecular:
    • Andrew G. Jobson,
    • George T. Lountos,
    • Philip L. Lorenzi,
    • Jenny Llamas,
    • John Connelly,
    • David Cerna,
    • Joseph E. Tropea,
    • Akikazu Onda,
    • Gabriele Zoppoli,
    • Sudhir Kondapaka,
    • Guangtao Zhang,
    • Natasha J. Caplen,
    • John H. Cardellina,
    • Stephen S. Yoo,
    • Anne Monks,
    • Christopher Self,
    • David S. Waugh,
    • Robert H. Shoemaker,
    • and Yves Pommier
    Cellular inhibition of Chk2 kinase and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 J Pharmacol Exp Ther ; published ahead of print September 9, 2009, doi:10.1124/jpet.109.154997
  26. Neuropharmacology:
    • Steven M. Grauer,
    • Virginia L. Pulito,
    • Rachel L. Navarra,
    • Michele Kelly,
    • Cody Kelley,
    • Radka Graf,
    • Barbara Langen,
    • Sheree Logue,
    • Julie Brennan,
    • Lixin Jiang,
    • Erik Charych,
    • Ute Egerland,
    • Feng Liu,
    • Karen L. Marquis,
    • Michael Malamas,
    • Thorsten Hage,
    • Thomas A. Comery,
    • and Nicholas J. Brandon
    PDE10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive and Negative Symptoms of Schizophrenia J Pharmacol Exp Ther ; published ahead of print August 6, 2009, doi:10.1124/jpet.109.155994
  27. Inflammation, Immunopharmacology, and Asthma:
    • Daniel S Lorrain,
    • Gretchen Bain,
    • Lucia D Correa,
    • Charles Chapman,
    • Alex Broadhead,
    • Angelina Santini,
    • Pat Prodanovich,
    • Janice Darlington,
    • John H Hutchinson,
    • Christopher King,
    • Catherine Lee,
    • Christopher Baccei,
    • Yiwei Li,
    • Jeannie Arruda,
    • and Jilly F Evans
    Pharmacological Characterization of AM103, a Novel Selective Five-lipoxygenase -Activating Protein (FLAP) Inhibitor Reduces Acute and Chronic Inflammation J Pharmacol Exp Ther ; published ahead of print September 11, 2009, doi:10.1124/jpet.109.158089
  28. Cardiovascular:
    • Vladimir V. Shuvaev,
    • Melpo Christofidou-Solomidou,
    • Faiz Bhora,
    • Karine Laude,
    • Hua Cai,
    • Sergey Dikalov,
    • Evguenia Arguiri,
    • Charalambos C. Solomides,
    • Steven M. Albelda,
    • David G. Harrison,
    • and Vladimir R. Muzykantov
    Targeted detoxification of selected reactive oxygen species in the vascular endothelium J Pharmacol Exp Ther ; published ahead of print August 19, 2009, doi:10.1124/jpet.109.156877
  29. METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:
    • Á. Pál,
    • D. Méhn,
    • É. Molnár,
    • S. Gedey,
    • P. Mészáros,
    • T. Nagy,
    • H. Glavinas,
    • T. Janáky,
    • O. von Richter,
    • G. Báthori,
    • L. Szente,
    • and P. Krajcsi
    Cholesterol Potentiates ABCG2 Activity in a Heterologous Expression System: Improved in Vitro Model to Study Function of Human ABCG2 J Pharmacol Exp Ther June 2007 321:1085-1094; published ahead of print March 8, 2007, doi:10.1124/jpet.106.119289
  30. METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:
    • Deshi Shi,
    • Jian Yang,
    • Dongfang Yang,
    • Edward L. LeCluyse,
    • Chris Black,
    • Li You,
    • Fatemeh Akhlaghi,
    • and Bingfang Yan
    Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel J Pharmacol Exp Ther December 2006 319:1477-1484; published ahead of print September 11, 2006, doi:10.1124/jpet.106.111807
  31. METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:
    • Fengyun Xu,
    • Valerie Y. Ng,
    • Deanna L. Kroetz,
    • and Paul R. Ortiz de Montellano
    CYP4 Isoform Specificity in the ω-Hydroxylation of Phytanic Acid, a Potential Route to Elimination of the Causative Agent of Refsum's Disease J Pharmacol Exp Ther August 2006 318:835-839; published ahead of print May 17, 2006, doi:10.1124/jpet.106.104976
  32. PERSPECTIVES IN PHARMACOLOGY:
    • Xingrong Liu,
    • Cuiping Chen,
    • and Bill J. Smith
    Progress in Brain Penetration Evaluation in Drug Discovery and Development J Pharmacol Exp Ther May 2008 325:349-356; published ahead of print January 18, 2008, doi:10.1124/jpet.107.130294
  33. Neuropharmacology:
    • Anna M. Nelson,
    • Gaynor A. Larson,
    • and Nancy R. Zahniser
    Low or high cocaine responding rats differ in striatal extracellular dopamine levels and dopamine transporter number J Pharmacol Exp Ther ; published ahead of print September 3, 2009, doi:10.1124/jpet.109.159897
  34. Perspectives in Pharmacology:
    • Liyun Wang,
    • Bronwen Martin,
    • Randall Brenneman,
    • Louis M Luttrell,
    • and Stuart R Maudsley
    Allosteric modulators of G protein-coupled receptors: Future therapeutics for complex physiological disorders J Pharmacol Exp Ther ; published ahead of print August 10, 2009, doi:10.1124/jpet.109.156380
  35. NEUROPHARMACOLOGY:
    • M. J. Millan,
    • A. Gobert,
    • F. Lejeune,
    • A. Dekeyne,
    • A. Newman-Tancredi,
    • V. Pasteau,
    • J.-M. Rivet,
    • and D. Cussac
    The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways J Pharmacol Exp Ther September 2003 306:954-964; published ahead of print May 15, 2003, doi:10.1124/jpet.103.051797
  36. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:
    • Tadashi Tsubouchi,
    • Takaharu Saito,
    • Fujie Mizutani,
    • Toshie Yamauchi,
    • and Yuji Iwanaga
    Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo J Pharmacol Exp Ther August 2003 306:787-793; published ahead of print April 30, 2003, doi:10.1124/jpet.102.048603
  37. Cardiovascular:
    • Hao Sun,
    • De-Pei Li,
    • Shao-Rui Chen,
    • Walter Hittelman,
    • and Hui-Lin Pan
    Sensing of Blood Pressure Increase by Transient Receptor Potential Vanilloid 1 Receptors on Baroreceptors J Pharmacol Exp Ther ; published ahead of print September 2, 2009, doi:10.1124/jpet.109.160473
  38. INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:
    • Jean-Pierre Evenou,
    • Jürgen Wagner,
    • Gerhard Zenke,
    • Volker Brinkmann,
    • Kathrin Wagner,
    • Jiri Kovarik,
    • Karl A. Welzenbach,
    • Gabriele Weitz-Schmidt,
    • Christine Guntermann,
    • Harry Towbin,
    • Sylvain Cottens,
    • Sandra Kaminski,
    • Thomas Letschka,
    • Christina Lutz-Nicoladoni,
    • Thomas Gruber,
    • Natascha Hermann-Kleiter,
    • Nikolaus Thuille,
    • and Gottfried Baier
    The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation J Pharmacol Exp Ther September 2009 330:792-801; published ahead of print June 2, 2009, doi:10.1124/jpet.109.153205
  39. METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:
    • Ying Chen,
    • Sagar Agarwal,
    • Naveed M. Shaik,
    • Cliff Chen,
    • Zheng Yang,
    • and William F. Elmquist
    P-glycoprotein and Breast Cancer Resistance Protein Influence Brain Distribution of Dasatinib J Pharmacol Exp Ther September 2009 330:956-963; published ahead of print June 2, 2009, doi:10.1124/jpet.109.154781
  40. ENDOCRINE AND DIABETES:
    • Kenji Katsuno,
    • Yoshikazu Fujimori,
    • Yukiko Takemura,
    • Masahiro Hiratochi,
    • Fumiaki Itoh,
    • Yoshimitsu Komatsu,
    • Hideki Fujikura,
    • and Masayuki Isaji
    Sergliflozin, a Novel Selective Inhibitor of Low-Affinity Sodium Glucose Cotransporter (SGLT2), Validates the Critical Role of SGLT2 in Renal Glucose Reabsorption and Modulates Plasma Glucose Level J Pharmacol Exp Ther January 2007 320:323-330; published ahead of print October 18, 2006, doi:10.1124/jpet.106.110296
  41. PERSPECTIVES IN PHARMACOLOGY:
    • Bin Liu and
    • Jau-Shyong Hong
    Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention J Pharmacol Exp Ther January 1, 2003 304:1-7; doi:10.1124/jpet.102.035048
  42. Inflammation, Immunopharmacology, and Asthma:
    • Heidi R Hope,
    • Gary D Anderson,
    • Barry L Burnette,
    • Robert P Compton,
    • Rajesh V Devraj,
    • Jeffrey L Hirsch,
    • Robert H Keith,
    • Xiong Li,
    • Gabriel Mbalaviele,
    • Dean M Messing,
    • Matthew J Saabye,
    • John F Schindler,
    • Shaun R Selness,
    • Loreen I Stillwell,
    • Elizabeth G Webb,
    • Jian Zhang,
    • and Joseph B Monahan
    Anti-inflammatory Properties of a Novel N-phenyl Pyridinone Inhibitor of p38 MAP Kinase: Preclinical to Clinical Translation J Pharmacol Exp Ther ; published ahead of print August 31, 2009, doi:10.1124/jpet.109.158329
  43. DRUG METABOLISM AND DISPOSITION:
    • Howard L. Kaplan,
    • Usoa E. Busto,
    • Godofredo J. Baylon,
    • Siu W. Cheung,
    • S. Victoria Otton,
    • Gail Somer,
    • and Edward M. Sellers
    Inhibition of Cytochrome P450 2D6 Metabolism of Hydrocodone to Hydromorphone Does Not Importantly Affect Abuse Liability J Pharmacol Exp Ther April 1, 1997 281:103-108
  44. Neuropharmacology:
    • Robert L. Martone,
    • Hua Zhou,
    • Kevin Atchison,
    • Thomas A. Comery,
    • Zheng Xu,
    • Xinyi Huang,
    • Xiaohai Gong,
    • Mei Jin,
    • Anthony Kreft,
    • Boyd Harrison,
    • Scott Mayer,
    • Suzan Aschmies,
    • Cathleen Gonzales,
    • Margaret M. Zaleska,
    • David Riddell,
    • Erik Wagner,
    • Peimin Lu,
    • Shaiu-Ching Sun,
    • June Sonnenberg-Reines,
    • Aram Oganesian,
    • Karissa Adkins,
    • Michael Leach,
    • David W. Clarke,
    • Donna Huryn,
    • Magid Abou-Gharbia,
    • Ronald Magolda,
    • Jonathan Bard,
    • Glen Frick,
    • Sangeeta Raje,
    • S. Bradley Forlow,
    • Carrie Balliet,
    • Michael E. Burczynski,
    • Peter Reinhart,
    • Hong Wan,
    • Menelas N. Pangalos,
    • and J. Steven Jacobsen
    GSI-953 (begacestat): A novel, selective thiophene sulfonamide inhibitor of APP γ-secretase for the treatment of Alzheimer's disease J Pharmacol Exp Ther ; published ahead of print August 11, 2009, doi:10.1124/jpet.109.152975
  45. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:
    • Rajinder K. Bhardwaj,
    • Hartmut Glaeser,
    • Laurent Becquemont,
    • Ulrich Klotz,
    • Suresh K. Gupta,
    • and Martin F. Fromm
    Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4 J Pharmacol Exp Ther August 1, 2002 302:645-650; doi:10.1124/jpet.102.034728
  46. Inflammation, Immunopharmacology, and Asthma:
    • Concetta Crisafulli,
    • Stefano Bruscoli,
    • Emanuela Esposito,
    • Emanuela Mazzon,
    • Rosanna Di Paola,
    • Tiziana Genovese,
    • Placido Bramanti,
    • Graziella Migliorati,
    • and Salvatore Cuzzocrea
    PPAR-α contributes to the anti-inflammatory activity of 17β-estradiol J Pharmacol Exp Ther ; published ahead of print September 15, 2009, doi:10.1124/jpet.109.156646
  47. Inflammation, Immunopharmacology, and Asthma:
    • HIDEO K TAKAHASHI,
    • KEYUE LIU,
    • HIDENORI WAKE,
    • SHUJI MORI,
    • JIYONG ZHANG,
    • RUI LIU,
    • TADASHI YOSHINO,
    • and MASAHIRO NISHIBORI
    Prostaglandins E2 inhibits advanced glycation end products-induced adhesion molecule expression, cytokine production and lymphocyte proliferation in human peripheral blood mononuclear cells J Pharmacol Exp Ther ; published ahead of print August 21, 2009, doi:10.1124/jpet.109.157594
  48. INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:
    • Victoria Boswell-Smith,
    • Domenico Spina,
    • Alec W. Oxford,
    • Mike B. Comer,
    • Esther A. Seeds,
    • and Clive P. Page
    The Pharmacology of Two Novel Long-Acting Phosphodiesterase 3/4 Inhibitors, RPL554 [9,10-Dimethoxy-2(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-Dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one] J Pharmacol Exp Ther August 2006 318:840-848; published ahead of print May 8, 2006, doi:10.1124/jpet.105.099192
  49. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:
    • Kyle A. Rasbach and
    • Rick G. Schnellmann
    Isoflavones Promote Mitochondrial Biogenesis J Pharmacol Exp Ther May 2008 325:536-543; published ahead of print February 11, 2008, doi:10.1124/jpet.107.134882
  50. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:
    • Helen H. Usansky and
    • Patrick J. Sinko
    Estimating Human Drug Oral Absorption Kinetics from Caco-2 Permeability Using an Absorption-Disposition Model: Model Development and Evaluation and Derivation of Analytical Solutions for ka and Fa J Pharmacol Exp Ther July 2005 314:391-399; published ahead of print April 15, 2005, doi:10.1124/jpet.104.076182

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