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Assistant Professor of Medicine (Clinician-Educator)

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Fast Forward: Last updated July 10, 2009 [View by date]

Papers published online before print

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PERSPECTIVES IN PHARMACOLOGY
BEHAVIORAL PHARMACOLOGY
CARDIOVASCULAR
CELLULAR AND MOLECULAR
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
NEUROPHARMACOLOGY

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PERSPECTIVES IN PHARMACOLOGY

Sabzali Javadov, Morris Karmazyn, and Nelson Escobales: Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases
Published June 9, 2009; doi: 10.1124/jpet.109.153213 [Abstract] [PDF]

BEHAVIORAL PHARMACOLOGY

Hiroyuki Mizoguchi, Kazuhiro Takuma, Emiko Fukuzaki, Daisuke Ibi, Eiichi Someya, Ko-hei Akazawa, Tursun Alkam, Hiroko Tsunekawa, Akihiro Mouri, Yukihiro Noda, Toshitaka Nabeshima, and Kiyofumi Yamada: Matrix metalloprotease-9 inhibition improves amyloid ${beta}$ -mediated cognitive impairment and neurotoxicity in mice
Published July 8, 2009; doi: 10.1124/jpet.109.154724 [Abstract] [PDF] [Data Supplement]

Kazuhiro Kubo, Koichi Nishikawa, Junko Ishizeki, Makiko Hardy-Yamada, Yuchio Yanagawa, and Shigeru Saito: Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase (GAD) 65
Published July 1, 2009; doi: 10.1124/jpet.109.156034 [Abstract] [PDF]

Wouter Koek, Susan L. Mercer, Andrew Coop, and Charles P. France: Behavioral effects of GHB, its precursor GBL, and GABA_B receptor agonists: time course, and differential antagonism by the GABA_B receptor antagonist CGP35348
Published June 29, 2009; doi: 10.1124/jpet.109.151845 [Abstract] [PDF]

Jannike Morch Andersen, Ase Ripel, Fernando Boix, Per Trygve Normann, and Jorg Morland: Increased locomotor activity induced by heroin in mice: Pharmacokinetic demonstration of heroin acting as a pro-drug for the mediator, 6-monoacetylmorphine, in vivo
Published June 18, 2009; doi: 10.1124/jpet.109.152462 [Abstract] [PDF]

Steven G. Kinsey, Jonathan Z. Long, Scott T. O'Neal, Rehab A. Abdullah, Justin L. Poklis, Dale L. Boger, Benjamin F. Cravatt, and Aron H. Lichtman: Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain
Published June 5, 2009; doi: 10.1124/jpet.109.155465 [Abstract] [PDF]

Robert E Sorge and Paul B.S. Clarke: Rats self-administer intravenous nicotine delivered in a novel smoking-relevant procedure: effects of dopamine antagonists
Published May 15, 2009; doi: 10.1124/jpet.109.154641 [Abstract] [PDF]

Mark A Smith, Jennifer L Greene-Naples, Jennifer N Felder, Jordan C Iordanou, Megan A Lyle, and Katherine L Walker: The effects of repeated opioid administration on locomotor activity: II. Unidirectional Cross-sensitization to cocaine
Published April 29, 2009; doi: 10.1124/jpet.108.150037 [Abstract] [PDF]

Mark A Smith, Jennifer L Greene-Naples, Megan A Lyle, Jordan C Iordanou, and Jennifer N Felder: The Effects of Repeated Opioid Administration on Locomotor Activity: I. Role of an Opioid's Relative Selectivity at Mu and Kappa Receptors
Published April 29, 2009; doi: 10.1124/jpet.108.150011 [Abstract] [PDF]

CARDIOVASCULAR

Vardan T Karamyan, Rama Gadepalli, John Rimoldi, and Robert Speth: Brain AT₁ angiotensin receptor subtype binding: Importance of peptidase inhibition for identification of angiotensin II as an endogenous ligand
Published July 8, 2009; doi: 10.1124/jpet.109.157461 [Abstract] [PDF]

Ismayil Ahmet, Chris Morrell, Edward G. Lakatta, and Mark I Talan: Therapeutic Efficacy of a Combination of a ${beta}$ 1 AR Blocker and ${beta}$ 2 AR Agonist in a Rat Model of Post-Myocardial Infarction Dilated Heart Failure Exceeds that of a ${beta}$ 1 AR Blocker plus ACE Inhibitor
Published July 8, 2009; doi: 10.1124/jpet.109.157107 [Abstract] [PDF] [Data Supplement]

Robert N Willette, Marianne E. Eybye, Alan R. Olzinski, David J. Behm, Nambi Aiyar, Kristeen Maniscalco, Ross G. Bentley, Robert W. Coatney, Shufang Zhao, Timothy Westfall, and Chris P. Doe: Differential Effects of p38 MAPK and COX2 Inhibitors in a Model of Cardiovascular Disease
Published June 25, 2009; doi: 10.1124/jpet.109.154443 [Abstract] [PDF] [Data Supplement]

Fabrice Vandeput, Judith Krall, Ramzi Ockaili, Fadi N Salloum, Vincent Florio, Jackie D. Corbin, Sharron H Francis, Rakesh C. Kukreja, and Matthew A. Movsesian: cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium
Published June 22, 2009; doi: 10.1124/jpet.109.154468 [Abstract] [PDF]

Anna Stadnicka, Stephen J Contney, Carol Moreno, Dorothee Weihrauch, Zeljko J Bosnjak, Richard J Roman, and Thomas A Stekiel: Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive (SS), Brown Norway (BN) and chromosome 13 substituted consomic rat strains: role of large conductance Ca²⁺ and voltage activated potassium (BK) channels
Published June 18, 2009; doi: 10.1124/jpet.109.154104 [Abstract] [PDF]

Cheuk-Kwan Sun, Fan-Yen Lee, Jiunn-Jye Sheu, Chun-Man Yuen, Sarah Chua, Sheng-Ying Chung, Han-Tan Chai, Yen-Ta Chen, Ying-Hsien Kao, Li-Teh Chang, and Hon-Kan Yip: Early Combined Treatment with Cilostazol and Bone Marrow-Derived Endothelial Progenitor Cells Markedly Attenuates Pulmonary Arterial Hypertension in Rats
Published June 15, 2009; doi: 10.1124/jpet.109.154328 [Abstract] [PDF]

Bruno Vie, Sylvie Sablayrolles, Robert Letienne, Bernard Vacher, Amaria Darmellah, Monique Bernard, Danielle Feuvray, and Bruno Le Grand: F 15845 prevents ischemia-induced heart remodeling by reduction of the intracellular Na⁺-overload
Published June 10, 2009; doi: 10.1124/jpet.109.153122 [Abstract] [PDF]

Hiromu Kawasaki, Shinji Eguchi, Satoko Miyashita, Shu Chan, Kazuhiro Hirai, Narumi Hobara, Ayako Yokomizo, Hidetoshi Fujiwara, Yoshito Zamami, Toshiro Koyama, Xin Jin, and Yoshihisa Kitamura: Proton acts as a neurotransmitter for nicotine-induced adrenergic and CGRPergic nerve-mediated vasodilation in the rat mesenteric artery
Published May 29, 2009; doi: 10.1124/jpet.108.149435 [Abstract] [PDF]

Andrew J. King, Jason A. Segreti, Kelly J. Larson, Andrew J. Souers, Philip R. Kym, Regina M. Reilly, Gang Zhao, Scott W. Mittelstadt, and Bryan F. Cox: Diacylglycerol acyltransferase 1 (DGAT-1) inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster
Published May 28, 2009; doi: 10.1124/jpet.109.154047 [Abstract] [PDF]

Hazem F. Elewa, Anna Kozak, Azza B. El-Remessy, Reginald F. Frye, Maribeth H. Johnson, Adviye Ergul, and Susan C. Fagan: Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats
Published May 28, 2009; doi: 10.1124/jpet.108.146951 [Abstract] [PDF]

Qin Xue and Lubo Zhang: Prenatal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: Role of PKC ${epsilon}$
Published May 26, 2009; doi: 10.1124/jpet.109.153239 [Abstract] [PDF]

Yong Chun Jin, Young Soo Lee, Young Min Kim, Hye Jung Kim, Han Geuk Seo, Jae Heun Lee, Hye Sook Yun-Choi, and Ki Churl Chang: CKD712, (S)-1-( ${alpha}$ -naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, reduces rat myocardial apoptosis against ischemia and reperfusion injury by activation of PI3K/Akt signaling and anti-inflammatory action in vivo
Published May 20, 2009; doi: 10.1124/jpet.108.150342 [Abstract] [PDF]

Takio Kitazawa, Koichi Asakawa, Tatsuro Nakamura, Hiroki Teraoka, Toshihiro Unno, Sei-ichi Komori, Masahisa Yamada, and Jurgen Wess: M₃ muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice
Published May 8, 2009; doi: 10.1124/jpet.109.153304 [Abstract] [PDF]

Anthie Ellis, Kenichi Goto, Daniel J. Chaston, Therese D. Brackenbury, Kate R. Meaney, John R. Falck, Richard J.H. Wojcikiewicz, and Caryl E. Hill: Enalapril treatment alters the contribution of EETs but not gap junctions to EDHF activity in mesenteric arteries of spontaneously hypertensive rats
Published May 1, 2009; doi: 10.1124/jpet.109.152116 [Abstract] [PDF]

Yuzhi Wu, Yejia Song, Luiz Belardinelli, and John C. Shryock: The late I_Na Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late I_Na and Cause Ventricular Diastolic Dysfunction
Published April 29, 2009; doi: 10.1124/jpet.109.151936 [Abstract] [PDF]

CELLULAR AND MOLECULAR

Martin Leduc, Billy Breton, Celine Gales, Christian Le Gouill, Michel Bouvier, Sylvain Chemtob, and Nikolaus Heveker: Functional selectivity of natural and synthetic prostaglandin EP₄ receptor ligands
Published July 7, 2009; doi: 10.1124/jpet.109.156398 [Abstract] [PDF] [Data Supplement]

Sara Rafferty, Nicole Alcolado, Caroline Norez, Frederic Chappe, Siegried Pelzer, Frederic Becq, and Valerie Chappe: Rescue of functional F508del-CFTR by VIP in the human nasal epithelial cell line JME/CF15
Published July 7, 2009; doi: 10.1124/jpet.109.155341 [Abstract] [PDF]

Pilar Almela, Noemi M Atucha, M. Victoria Milanes, and Maria Luisa Laorden: Crosstalk between PKA and MAP kinases signalling in the adaptive changes observed during morphine withdrawal in the heart
Published June 30, 2009; doi: 10.1124/jpet.109.154583 [Abstract] [PDF]

Santos M. Nicolau, Antonio M. G. de Diego, Lorena Cortes-Gil, Francisco Javier Egea Maiquez, Jose C. Gonzalez, Marta Mosquera, Manuela G Lopez, Jesus Miguel Hernandez-Guijo, and ANTONIO G. GARCIA: Mitochondrial Na⁺/Ca²⁺-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine
Published June 9, 2009; doi: 10.1124/jpet.109.154765 [Abstract] [PDF]

Srividya Suryanarayana, Martin Gottle, Melanie Hubner, Andreas Gille, Tung-Chung Mou, Stephen R Sprang, Mark Richter, and Roland Seifert: Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2',3'-O-(2,4,6-Trinitrophenyl)-Substituted Nucleoside 5'-Triphosphates
Published June 3, 2009; doi: 10.1124/jpet.109.155432 [Abstract] [PDF]

Antonella Caputo, Alexandre Hinzpeter, Emanuela Caci, Nicoletta Pedemonte, Nicole Arous, Marco Di Duca, Olga Zegarra-Moran, Pascale Fanen, and Luis JV Galietta: MUTATION-SPECIFIC POTENCY AND EFFICACY OF CFTR CHLORIDE CHANNEL POTENTIATORS
Published June 2, 2009; doi: 10.1124/jpet.109.154146 [Abstract] [PDF]

Kevin M Walton, Katherine Fisher, David Rubitski, Michael Marconi, Qing-Jun Meng, Martin Sladek, Jessica Adams, Michael Bass, Rama Chandrasekaran, Todd Butler, Matt Griffor, Francis Rajamohan, Megan Serpa, Yuhpyng Chen, Michelle Claffey, Michael Hastings, Andrew Loudon, Elizabeth Maywood, Jeffrey Ohren, Angela Doran, and Travis T Wager: Selective Inhibition of Casein Kinase 1 Epsilon Minimally Alters Circadian Clock Period
Published May 19, 2009; doi: 10.1124/jpet.109.151415 [Abstract] [PDF] [Data Supplement]

De-Ming Yang, Hsiao-Chuan Teng, Kuan-Hsuan Chen, Ming-Long Tsai, Ting-Kuei Lee, Yueh-Ching Chou, Chin-Wen Chi, Shi-Hwa Chiou, and Chen-Hsen Lee: Clodronate-induced cell apoptosis in human thyroid carcinoma is mediated via the P2 receptor signaling pathway
Published May 15, 2009; doi: 10.1124/jpet.109.152447 [Abstract] [PDF]

Nisha Kurian, Caroline J Hall, Graeme F Wilkinson, Michael Sullivan, Andrew B Tobin, and Gary B Willars: Full and partial agonists of muscarinic M₃ receptors reveal single and oscillatory Ca²⁺ responses by ${beta}$ ₂-adrenoceptors
Published May 6, 2009; doi: 10.1124/jpet.109.153619 [Abstract] [PDF]

Moshe Y Levy, Abhinav Sidana, Wasim H Chowdhury, Steven B Solomon, Charles G Drake, Ronald Rodriguez, and Ephraim J Fuchs: Cyclophosphamide unmasks an anti-metastatic effect of local tumor cryoablation
Published April 30, 2009; doi: 10.1124/jpet.109.152603 [Abstract] [PDF]

CHEMOTHERAPY, ANTIBIOTICS, & GENE THERAPY

Mark S. Swingle, Lauren Amable, Brian G. Lawhorn, Suzanne B. Buck, Christopher P. Burke, Pukar Ratti, Kimberly L. Fischer, Dale L. Boger, and Richard E. Honkanen: Structure-Activity Relationship Studies of Fostriecin, Cytostatin and Key Analogues, with PP1, PP2A, PP5, and ( ${beta}$ 12- ${beta}$ 13)-chimeras (PP1/PP2A and PP5/PP2A) Provide Further Insight Into Inhibitory Actions of Fostriecin Family Inhibitors
Published July 10, 2009; doi: 10.1124/jpet.109.155630 [Abstract] [PDF]

Fei Shen, Barbara J. Bailey, Shaoyou Chu, Aimee K. Bence, Xinjian Xue, Priscilla Erickson, Ahmad R. Safa, William T. Beck, and Leonard C. Erickson: Dynamic Assessment of Mitoxantrone Resistance and Modulation of Multidrug Resistance by PSC833 in Multidrug Resistant Human Cancer Cells
Published May 7, 2009; doi: 10.1124/jpet.109.153551 [Abstract] [PDF]

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Sara M. Camp, Robert Bittman, Eddie T. Chiang, Liliana Moreno-Vinasco, Tamara Mirzapoiazova, Saad Sammani, Xuequan Lu, Chaode Sun, Mark Harbeck, Michael Roe, Viswanathan Natarajan, Joe G.N. Garcia, and Steven M. Dudek: Synthetic analogues of FTY720 differentially regulate pulmonary vascular permeability in vivo and in vitro
Published July 10, 2009; doi: 10.1124/jpet.109.153544 [Abstract] [PDF]

Bernard Fromenty, Nathalie Vadrot, Julie Massart, Bruno Turlin, Nadege Barri-Ova, Philippe Letteron, Alain Fautrel, and Marie-Anne Robin: Chronic ethanol consumption lessens the gain of body weight, liver triglycerides and diabetes in obese ob/ob mice
Published July 8, 2009; doi: 10.1124/jpet.109.155168 [Abstract] [PDF]

Mark W Musch, Donna L Arvans, Herve Paris, and Eugene Chang: Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3
Published June 25, 2009; doi: 10.1124/jpet.109.151910 [Abstract] [PDF]

Teita Asano, Ken-Ichiro Tanaka, Naoki Yamakawa, Hiroaki Adachi, Gen Sobue, Hidemi Goto, Koji Takeuchi, and Tohru Mizushima: HSP70 CONFERS PROTECTION AGAINST INDOMETHACIN-INDUCED LESIONS OF THE SMALL INTESTINE
Published June 11, 2009; doi: 10.1124/jpet.109.152181 [Abstract] [PDF] [Data Supplement]

Florenta Aura Kullmann, Brian J Limberg, Debra E Artim, Mansi Shah, Thomas R Down, Dan Contract, John Wos, Jan S Rosenbaum, and William Chet de Groat: Effects of beta 3 adrenergic receptor activation on rat urinary bladder hyperactivity induced by ovariectomy
Published June 10, 2009; doi: 10.1124/jpet.109.155010 [Abstract] [PDF] [Data Supplement]

Dulce Soler, Tobias Chapman, Li-Li Yang, Tim Wyant, Robert Egan, and Eric R. Fedyk: The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti- ${alpha}$ ₄ ${beta}$ ₇ Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases
Published June 9, 2009; doi: 10.1124/jpet.109.153973 [Abstract] [PDF]

Jand Venes R Medeiros, Victor H Bezerra, Antoniella S Gomes, Andre Luiz R Barbosa, Roberto Cesar P Lima-Junior, Pedro Marcos G Soares, Gerly Anne C Brito, Ronaldo A Ribeiro, Fernando Queiroz Cunha, and Marcellus H L P Souza: HYDROGEN SULPHIDE PREVENTS ETHANOL-INDUCED GASTRIC DAMAGE IN MICE: ROLE OF K_ATP CHANNELS AND CAPSAICIN-SENSITIVE PRIMARY AFFERENT NEURONS
Published June 2, 2009; doi: 10.1124/jpet.109.152801 [Abstract] [PDF]

Paola Casarosa, Thierry Bouyssou, Sabine Germeyer, Andreas Schnapp, Florian Gantner, and Michael P Pieper: Preclinical evaluation of Long Acting Muscarinic Antagonists (LAMAs): comparison of tiotropium and investigational drugs
Published May 28, 2009; doi: 10.1124/jpet.109.152470 [Abstract] [PDF]

Ji-Hyun Kim, Seong-Hae Park, Young Wha Moon, Sungmin Hwang, Donghoon Kim, Su-Hyun Jo, Seog Bae Oh, Joong Soo Kim, Jeong Won Jahng, Jong-Ho Lee, Sung Joong Lee, Se-Young Choi, and Kyungpyo Park: Histamine H1 Receptor Induces Cytosolic Calcium Increase And Aquaporin Translocation In Human Salivary Gland Cells
Published May 14, 2009; doi: 10.1124/jpet.109.153023 [Abstract] [PDF] [Data Supplement]

Shih-Lu Wu, Jaw-Chyun Chen, Chia-Cheng Li, Hsin-Yi Lo, Tin-Yun Ho, and Chien-Yun Hsiang: Vanillin Improves and Prevents Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice
Published May 7, 2009; doi: 10.1124/jpet.109.152835 [Abstract] [PDF]

James A. Tumlin, Brian R. Roberts, Kenneth E. Kokko, Osama El Minshawy, and Jennifer L. Gooch: T cell receptor stimulated calcineurin activity is inhibited in isolated T cells from transplant patients
Published May 6, 2009; doi: 10.1124/jpet.109.154096 [Abstract] [PDF]

Sara M. Camp, Robert Bittman, Eddie T. Chiang, Liliana Moreno-Vinasco, Tamara Mirzapoiazova, Saad Sammani, Xuequan Lu, Chaode Sun, Mark Harbeck, Michael Roe, Viswanathan Natarajan, Joe G.N. Garcia, and Steven M. Dudek: Synthetic analogues of FTY720 differentially regulate pulmonary vascular permeability in vivo and in vitro
Published July 10, 2009; doi: 10.1124/jpet.109.153544 [Abstract] [PDF]

Bernard Fromenty, Nathalie Vadrot, Julie Massart, Bruno Turlin, Nadege Barri-Ova, Philippe Letteron, Alain Fautrel, and Marie-Anne Robin: Chronic ethanol consumption lessens the gain of body weight, liver triglycerides and diabetes in obese ob/ob mice
Published July 8, 2009; doi: 10.1124/jpet.109.155168 [Abstract] [PDF]

Mark W Musch, Donna L Arvans, Herve Paris, and Eugene Chang: Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3
Published June 25, 2009; doi: 10.1124/jpet.109.151910 [Abstract] [PDF]

Teita Asano, Ken-Ichiro Tanaka, Naoki Yamakawa, Hiroaki Adachi, Gen Sobue, Hidemi Goto, Koji Takeuchi, and Tohru Mizushima: HSP70 CONFERS PROTECTION AGAINST INDOMETHACIN-INDUCED LESIONS OF THE SMALL INTESTINE
Published June 11, 2009; doi: 10.1124/jpet.109.152181 [Abstract] [PDF] [Data Supplement]

Florenta Aura Kullmann, Brian J Limberg, Debra E Artim, Mansi Shah, Thomas R Down, Dan Contract, John Wos, Jan S Rosenbaum, and William Chet de Groat: Effects of beta 3 adrenergic receptor activation on rat urinary bladder hyperactivity induced by ovariectomy
Published June 10, 2009; doi: 10.1124/jpet.109.155010 [Abstract] [PDF] [Data Supplement]

Dulce Soler, Tobias Chapman, Li-Li Yang, Tim Wyant, Robert Egan, and Eric R. Fedyk: The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti- ${alpha}$ ₄ ${beta}$ ₇ Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases
Published June 9, 2009; doi: 10.1124/jpet.109.153973 [Abstract] [PDF]

Jand Venes R Medeiros, Victor H Bezerra, Antoniella S Gomes, Andre Luiz R Barbosa, Roberto Cesar P Lima-Junior, Pedro Marcos G Soares, Gerly Anne C Brito, Ronaldo A Ribeiro, Fernando Queiroz Cunha, and Marcellus H L P Souza: HYDROGEN SULPHIDE PREVENTS ETHANOL-INDUCED GASTRIC DAMAGE IN MICE: ROLE OF K_ATP CHANNELS AND CAPSAICIN-SENSITIVE PRIMARY AFFERENT NEURONS
Published June 2, 2009; doi: 10.1124/jpet.109.152801 [Abstract] [PDF]

Paola Casarosa, Thierry Bouyssou, Sabine Germeyer, Andreas Schnapp, Florian Gantner, and Michael P Pieper: Preclinical evaluation of Long Acting Muscarinic Antagonists (LAMAs): comparison of tiotropium and investigational drugs
Published May 28, 2009; doi: 10.1124/jpet.109.152470 [Abstract] [PDF]

Ji-Hyun Kim, Seong-Hae Park, Young Wha Moon, Sungmin Hwang, Donghoon Kim, Su-Hyun Jo, Seog Bae Oh, Joong Soo Kim, Jeong Won Jahng, Jong-Ho Lee, Sung Joong Lee, Se-Young Choi, and Kyungpyo Park: Histamine H1 Receptor Induces Cytosolic Calcium Increase And Aquaporin Translocation In Human Salivary Gland Cells
Published May 14, 2009; doi: 10.1124/jpet.109.153023 [Abstract] [PDF] [Data Supplement]

Shih-Lu Wu, Jaw-Chyun Chen, Chia-Cheng Li, Hsin-Yi Lo, Tin-Yun Ho, and Chien-Yun Hsiang: Vanillin Improves and Prevents Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice
Published May 7, 2009; doi: 10.1124/jpet.109.152835 [Abstract] [PDF]

James A. Tumlin, Brian R. Roberts, Kenneth E. Kokko, Osama El Minshawy, and Jennifer L. Gooch: T cell receptor stimulated calcineurin activity is inhibited in isolated T cells from transplant patients
Published May 6, 2009; doi: 10.1124/jpet.109.154096 [Abstract] [PDF]

NEUROPHARMACOLOGY

Samir Haj-Dahmane and Roh-Yu Shen: Endocannabinoids Suppress Excitatory Synaptic Transmission to Dorsal Raphe Serotonin Neurons through the Activation of Presynaptic CB₁ Receptors
Published July 10, 2009; doi: 10.1124/jpet.109.153858 [Abstract] [PDF]

Julian Albarran, Ralf Gilsbach, Roland Piekorz, Katrin Pexa, Nadine Beetz, Johanna Schneider, Bernd Nuernberg, and Lutz Hein: Modulation of ${alpha}$ ₂-adrenoceptor functions by heterotrimeric G ${alpha}$ _i protein isoforms
Published July 9, 2009; doi: 10.1124/jpet.109.157230 [Abstract] [PDF]

Keiji Nishiyama, Yasushi Shintani, Keisuke Hirai, and Shin-ichi Yoshikubo: Molecular Cloning and Pharmacological Characterization of Monkey MT₁ and MT₂ Melatonin Receptors Showing High Affinity for the Agonist Ramelteon
Published June 25, 2009; doi: 10.1124/jpet.109.155283 [Abstract] [PDF]

Tzu-Ching Kuo, Jai-Sing Yang, Meng-Wei Lin, Shu-Chun Hsu, Jen-Jyh Lin, Hui-Ju Lin, Te-Chun Hsia, Ching-Lung Liao, Mei-Due Yang, Ming-Jen Fan, W. G. Wood, and Jing-Gung Chung: Emodin has cytotoxic and protective effects in Rat C6 glioma cells: Roles of Mdr1a and NF-kappa B in cell survival
Published June 23, 2009; doi: 10.1124/jpet.109.153007 [Abstract] [PDF] [Data Supplement]

Michael C. Montana, Laura F. Cavallone, Kristi K. Stubbert, Andrei D. Stefanescu, Evan D. Kharasch, and Robert W. Gereau: The mGlu5 antagonist fenobam is analgesic and has improved in vivo selectivity as compared to the prototypical antagonist MPEP
Published June 10, 2009; doi: 10.1124/jpet.109.154138 [Abstract] [PDF]

Leah Hanson, Annina Roeytenberg, Paula M. Martinez, Valerie G. Coppes, Donald C. Sweet, Reshma J. Rao, Dianne L. Marti, John D. Hoekman, Rachel B. Matthews, William H. Frey, and S. Scott Panter: Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke
Published June 9, 2009; doi: 10.1124/jpet.108.149807 [Abstract] [PDF]

Kelly Conlon, Clare Christy, Simon Westbrook, Gavin Whitlock, Lee Roberts, Alan Stobie, and Gordon McMurray: Pharmacological properties of 2-((R-5-Chloro-4-methoxymethyl-indan-1-yl)-1H-imidazole (PF-3774076), a novel and selective ${alpha}$ 1_A adrenergic partial agonist in in vitro and in vivo models of urethral function
Published June 4, 2009; doi: 10.1124/jpet.109.154963 [Abstract] [PDF] [Data Supplement]

Anton Pekcec, Bernadette Unkruer, Juli Schlichtiger, Jonna Soerensen, Anika M.S. Hartz, Bjoern Bauer, Erwin A. van Vliet, Jan A. Gorter, and Heidrun Potschka: TARGETING PROSTAGLANDIN E₂ EP1 RECEPTORS PREVENTS SEIZURE-ASSOCIATED P-GLYCOPROTEIN UP-REGULATION
Published June 3, 2009; doi: 10.1124/jpet.109.152520 [Abstract] [PDF]

Zhu Li, Adam J Prus, Jin Dai, and Herbert Y Meltzer: Differential effects of M₁ and 5-HT_1A receptors on atypical antipsychotic drug-induced dopamine efflux in the medial prefrontal cortex
Published June 2, 2009; doi: 10.1124/jpet.109.155663 [Abstract] [PDF]

Suneeta Tumati, Henry I. Yamamura, Todd W. Vanderah, William R. Roeske, and Eva V. Varga: Sustained morphine treatment augments capsaicin-evoked CGRP release from primary sensory neurons in a PKA and Raf-1- dependent manner
Published June 2, 2009; doi: 10.1124/jpet.109.151704 [Abstract] [PDF]

Gianluigi Tanda, Amy Newman, Aaron L. Ebbs, Valeria Tronci, Jennifer Green, Ronald J. Tallarida, and Jonathan L. Katz: Combinations of Cocaine with other Dopamine Uptake Inhibitors: Assessment of Additivity
Published May 29, 2009; doi: 10.1124/jpet.109.154302 [Abstract] [PDF]

Yan Chen, Fang Luo, Cheng Yang, Chelsea Kirkmire, and Zaijie Jim Wang: Acute inhibition of Ca²⁺/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice
Published May 28, 2009; doi: 10.1124/jpet.109.152165 [Abstract] [PDF]

Yael Mardor, David Last, Dianne Daniels, Ran Shneor, Stephan E Maier, Dvora Nass, and Zvi Ram: Convection enhanced delivery of IL-4 pseudomonas exotoxin (PRX321): Increased distribution and MR monitoring
Published May 28, 2009; doi: 10.1124/jpet.109.154401 [Abstract] [PDF]

Yang Gao and Stephen Brimijoin: Lasting Reduction of Cocaine Action in Neostriatum-A Hydrolase Gene Therapy Approach
Published May 28, 2009; doi: 10.1124/jpet.109.152231 [Abstract] [PDF] [Data Supplement]

Resat Cinar and Maria Szucs: CB₁ receptor-independent actions of SR141716 on G-protein signaling; co-application with the µ-opioid agonist DAMGO unmasks novel, pertussis toxin-insensitive opioid signaling in MOR-CHO cells
Published May 15, 2009; doi: 10.1124/jpet.109.152710 [Abstract] [PDF]

Sunil Sirohi, Shveta V. Dighe, Priyanka A. Madia, and Byron C. Yoburn: The Relative Potency of Inverse Opioid Agonists and A Neutral Opioid Antagonist in Precipitated Withdrawal and Antagonism of Analgesia and Toxicity
Published May 12, 2009; doi: 10.1124/jpet.109.152678 [Abstract] [PDF]

Kia J. Jackson, Carrie L. Walters, and M. Imad Damaj: ${beta}$ 2 subunit-containing Nicotinic Receptors Mediate Acute Nicotine-induced Activation of CaMKII-dependent Pathways in vivo
Published May 12, 2009; doi: 10.1124/jpet.109.153171 [Abstract] [PDF]

Jason C. Reneau, Mary E. Reyland, Jonathan Phillips, Carissa Kindy, and Roseanna Lisa Popp: Phorbol 12-myristate 13-acetate potentiation of N-Methyl-D-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by Protein Kinase C ${alpha}$
Published May 8, 2009; doi: 10.1124/jpet.109.153163 [Abstract] [PDF]

Yan L. Dong, Yan Zhu, Yi Dong, Hui J. Yang, Yan Y. Zhao, Jie Y. Qi, Ying P. Wu, Hua Y. Zhu, and Ping Zheng: Neuroactive steroid dehydroepiandrosterone sulphate inhibits 5-HT-evoked glutamate release via activation of sigma-1 receptors and then inhibition of 5-HT₃ receptors in rat prelimbic cortex
Published May 6, 2009; doi: 10.1124/jpet.109.154294 [Abstract] [PDF]

Maria F.M. Braga, Vassiliki Aroniadou-Anderjaska, He Li, and Michael A. Rogawski: Topiramate Reduces Excitability in the Basolateral Amygdala by Selectively Inhibiting GluK1 (GluR5) Kainate Receptors on Interneurons and Positively Modulating GABA_A Receptors on Principal Neurons
Published May 5, 2009; doi: 10.1124/jpet.109.153908 [Abstract] [PDF]