QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Fast Forward: Last updated July 3, 2008 [View by date]

Papers published online before print

About JPET Fast Forward:

PERSPECTIVES IN PHARMACOLOGY
BEHAVIORAL PHARMACOLOGY
CARDIOVASCULAR
CELLULAR AND MOLECULAR
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
ENDOCRINE AND DIABETES
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
NEUROPHARMACOLOGY
TOXICOLOGY

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

---

PERSPECTIVES IN PHARMACOLOGY

James E. Barrett and Jack Bergman

Centennial Perspective: Peter B. Dews and Pharmacological Studies on Behavior
Published June 10, 2008; doi: 10.1124/jpet.108.139261 [Abstract] [PDF]  

Jie Liu, Yuanfu Lu, Qin Wu, Robert A Goyer, and Michael P Waalkes

Mineral Aresenicals in Traditional Medicines: Orpiment, Realgar, and Arsenolite
Published May 7, 2008; doi: 10.1124/jpet.108.139543 [Abstract] [PDF]  

---

BEHAVIORAL PHARMACOLOGY

Roberto Coccurello, Antonio Caprioli, Roberto Conti, Orlando Ghirardi, Franco Borsini, Paolo Carminati, and Anna Moles

Olanzapine but not the novel atypical antipsychotic ST2472 chronic administration induces weight gain, hyperphagia and metabolic dysregulation in mice
Published June 20, 2008; doi: 10.1124/jpet.108.137240 [Abstract] [PDF]  

Ziva D Cooper, Yen N Truong, Yong-Gong Shi, and James H Woods

Morphine deprivation increases self-administration of the fast- and short-acting mu-opioid receptor agonist remifentanil in the rat
Published May 30, 2008; doi: 10.1124/jpet.108.139196 [Abstract] [PDF]  

Gail Pereira Do Carmo, Robin Polt, Edward J. Bilsky, Kenner C. Rice, and S. Stevens Negus

Behavioral Pharmacology of the Mu/Delta Opioid Glycopeptide MMP2200 in Rhesus Monkeys
Published May 29, 2008; doi: 10.1124/jpet.108.138180 [Abstract] [PDF]  

Thierry Bordet, Bruno Buisson, Magali Michaud, Jean-Louis Abitbol, Fabien Marchand, John Grist, Emile Andriambeloson, Marzia Malcangio, and Rebecca M Pruss

Specific antinociceptive activity of cholest-4-en-3-one,oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy
Published May 20, 2008; doi: 10.1124/jpet.108.139410 [Abstract] [PDF] [Data Supplement]  

Geoffrey B Varty, Sherry X Lu, Cynthia A Morgan, Mary E Cohen-Williams, Robert A Hodgson, April Smith-Torhan, Hongtao Zhang, Ahmad B Fawzi, Michael P Graziano, Ginny D Ho, Julius Matasi, Deen Tulshian, Vicki L Coffin, and Galen J Carey

The anxiolytic-like effects of the novel, orally active nociceptin NOP receptor agonist, 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510)
Published May 20, 2008; doi: 10.1124/jpet.108.136937 [Abstract] [PDF]  

KATSUYA MORITA, NAOYO MOTOYAMA, TOMOYA KITAYAMA, NORIMITSU MORIOKA, KOKI KIFUNE, and TOSHIHIRO DOHI

Spinal Anti-Allodynia Action of Glycine Transporter Inhibitors in Neuropathic Pain Models in Mice
Published April 30, 2008; doi: 10.1124/jpet.108.136267 [Abstract] [PDF]  

---

CARDIOVASCULAR

Taeko Matsuda, Yumiko Toyohira, Susumu Ueno, Masato Tsutsui, and Nobuyuki Yanagihara

Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na⁺ and Ca²⁺ influx in bovine adrenal medullary cells
Published July 1, 2008; doi: 10.1124/jpet.108.139659 [Abstract] [PDF]  

Julie L. Hawkins, Michael D. Robbins, Laurie C. Warren, Donghui Xia, Stephen F. Petras, James J. Valentine, Alison H. Varghese, Ing-Kae Wang, Timothy A. Subashi, Lorraine D. Shelly, Bruce A. Hay, Katherine T. Landschulz, Kieran F. Geoghegan, and H. James Harwood

Pharmacologic inhibition of site-1 protease activity inhibits SREBP processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals
Published June 24, 2008; doi: 10.1124/jpet.108.139626 [Abstract] [PDF]  

Young Mi Seok, Inji Baek, Yong-Hoon Kim, Yeon-Shin Jeong, In-Jung Lee, Dong Hyun Shin, Young Hyun Hwang, and InKyeom Kim

Isoflavone attenuates vascular contraction through inhibition of RhoA/Rho-kinase signaling pathway
Published June 24, 2008; doi: 10.1124/jpet.108.138529 [Abstract] [PDF]  

Wieslaw Kozak, Anna Kozak, Maribeth H Johnson, Hazem F Elewa, and Susan C Fagan

Vascular protection with candesartan after experimental stroke in hypertensive rats: A dose-response study
Published June 17, 2008; doi: 10.1124/jpet.108.139618 [Abstract] [PDF]  

Chin-Wei Chiao, Rita C. Tostes, and R. Clinton Webb

P2X₇ receptor activation amplifies lipopolysaccharide-induced vascular hyporeactivity via interleukin-1 release
Published June 16, 2008; doi: 10.1124/jpet.107.135350 [Abstract] [PDF]  

Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi, and Kenji Kuwabara

A long-acting and highly selective prostacyclin receptor agonist prodrug, NS-304, ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, MRE-269, on rat pulmonary artery
Published June 13, 2008; doi: 10.1124/jpet.108.138305 [Abstract] [PDF]  

Huige Li, Marcus Hortmann, Andreas Daiber, Matthias Oelze, Mir Abolfazl Ostad, Petra M Schwarz, Hui Xu, Ning Xia, Andrei L Kleschyov, Christian Mang, Ascan Warnholtz, Thomas Munzel, and Ulrich Forstermann

COX2-selective and non-selective NSAIDs induce oxidative stress by upregulating vascular NADPH oxidases
Published June 13, 2008; doi: 10.1124/jpet.108.139030 [Abstract] [PDF]  

Qinghua Zeng, Qingwei Zhou, Fanrong Yao, Stephen T. O'Rourke, and Chengwen Sun

Endothelin-1 Regulates Cardiac L-Type Calcium Channels via NAD(P)H Oxidase-Derived Superoxide
Published June 6, 2008; doi: 10.1124/jpet.108.140301 [Abstract] [PDF]  

Marcella Rocchetti, Matteo Alemanni, Gaspare Mostacciuolo, Paolo Barassi, Claudia Altomare, Riccardo Chisci, Rosella Micheletti, Patrizia Ferrari, and Antonio Zaza

Modulation of sarcoplasmic reticulum function by istaroxime (PST2744) in a pressure-overload heart failure model
Published June 6, 2008; doi: 10.1124/jpet.108.138701 [Abstract] [PDF] [Data Supplement]  

Christopher Morrey, Rima Estephan, Geoffrey W. Abbott, and Roberto Levi

Cardioprotective Effect of Histamine H₃-Receptor Activation: Pivotal Role of G-Dependent Inhibition of Voltage-Operated Ca²⁺ Channels
Published June 3, 2008; doi: 10.1124/jpet.108.137919 [Abstract] [PDF]  

Lorraine Yau, Peter Molnar, Michael C. Moon, Shelly Buhay, Jeffrey P. Werner, Katerina Molnar, Laura Saward, Dario Del Rizzo, and Peter Zahradka

Meta-Iodobenzylguanidine, an Inhibitor of Arginine-dependent Mono(ADP-ribosyl)ation, Prevents Neointimal Hyperplasia
Published June 3, 2008; doi: 10.1124/jpet.108.137513 [Abstract] [PDF]  

Robert Willette, Weike Bao, Sandhya Nerurkar, Tian-li Yue, Chris P Doe, Gerald Stankus, Gregory H Turner, Haisong Ju, Heath Thomas, Cynthia Fishman, Anthony Sulpizio, David Behm, Sandra Hoffman, Zuojun Lin, Irina Lozinskaya, Linda Casillas, Min Lin, Robert E. Lee Trout, Kevin Thorneloe, Erin SR Lashinger, David J Figueroa, Bartholomew Votta, Robert Marquis, and Xiaoping Xu

Systemic Activation of the Transient Receptor Potential V4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2
Published May 27, 2008; doi: 10.1124/jpet.107.134551 [Abstract] [PDF] [Data Supplement]  

Bishara Bishara, Hiba Shiekh, Tony Karram, Irit Rubinstein, Zaher Azzam, Niroz Abu-Saleh, Samy Nitecki, Joseph Winaver, Aaron Hoffman, and Zaid Abassi

Effects of novel vasopressin receptor antagonists on renal function and cardiac hypertrophy in rats with experimental congestive heart failure
Published May 8, 2008; doi: 10.1124/jpet.108.137745 [Abstract] [PDF]  

DongFang Wu, Hong Yang, YangFeng Zhao, Chakradhari Sharan, J. Shawn Goodwin, Lichun Zhou, Yang Guo, and Zhongamao Guo

2-Aminopurine inhibits lipid accumulation induced by apolipoprotein E-deficient lipoprotein in macrophages: potential role of eIF-2 phosphorylation in foam cell formation
Published May 7, 2008; doi: 10.1124/jpet.107.134833 [Abstract] [PDF]  

Takahiro Nagayama, Manling Zhang, Steven Hsu, Eiki Takimoto, and David A. Kass

Sustained Soluble Guanylate Cyclase Stimulation offsets NOS Inhibition to Restore Acute Cardiac Modulation by Sildenafil
Published May 2, 2008; doi: 10.1124/jpet.108.137422 [Abstract] [PDF] [Data Supplement]  

---

CELLULAR AND MOLECULAR

Austin Meng Guo, Ju Sheng, Gloria M Scicli, Ali S Arbab, Norman L Lehman, Paul A Edwrads, John R Falck, Richard J Roman, and Alfonso G Scicli

Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in vitro and Rapidly Growing Tumors in vivo
Published June 30, 2008; doi: 10.1124/jpet.108.140889 [Abstract] [PDF]  

Haoyu Zeng, Earl A. Gordon, Zuojun Lin, Irina M. Lozinskaya, Robert N. Willette, and Xiaoping Xu

1-[1-hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone (HMIMP), a Potent and Highly Selective Small Molecule Blocker of the Large-Conductance Voltage-gated and Calcium-dependent K⁺ Channel
Published June 30, 2008; doi: 10.1124/jpet.108.139733 [Abstract] [PDF]  

Andrea Strasser, Hans-Joachim Wittmann, and Roland Seifert

Ligand-Specific Contribution of the N-Terminus and E2-Loop to Pharmacological Properties of the Histamine H₁-Receptor
Published June 24, 2008; doi: 10.1124/jpet.108.140913 [Abstract] [PDF]  

Telma Roque, Emilie Boncoeur, Vinciane Saint-Criq, Elise Bonvin, Annick Clement, Olivier Tabary, and Jacky Jacquot

Pro-inflammatory effect of sodium 4-phenylbutyrate in F508-CFTR lung epithelial cells: Involvement of ERK1/2 and JNK signaling
Published June 23, 2008; doi: 10.1124/jpet.107.135186 [Abstract] [PDF]  

Richard R. Almon, Eric Yang, William Lai, Ioannis P Androulakis, Debra C DuBois, and William J. Jusko

Circadian Variations in Liver Gene Expression: Relationships to Drug Actions
Published June 18, 2008; doi: 10.1124/jpet.108.140186 [Abstract] [PDF] [Data Supplement]  

Nora Bijl, Saskia Scheij, Sander M. Houten, Rolf G. Boot, Albert K. Groen, and Johannes M. F. G. Aerts

The glucosylceramide synthase inhibitor AMP-DNM induces SREBP regulated gene expression and cholesterol synthesis in HepG2 cells
Published June 12, 2008; doi: 10.1124/jpet.108.139394 [Abstract] [PDF] [Data Supplement]  

Andreas Koeberle, Ulf Siemoneit, Ulrike Buehring, Hinnak Northoff, Stefan Laufer, Wolfgang Albrecht, and Oliver Werz

Licofelone suppresses prostaglandin E₂ formation by interference with the inducible microsomal prostaglandin E₂ synthase-1
Published June 11, 2008; doi: 10.1124/jpet.108.139444 [Abstract] [PDF]  

Morley D. Hollenberg, Bernard Renaux, Eric Hyun, Steeve Houle, Nathalie Vergnolle, Mahmoud Saifeddine, and Rithwik Ramachandran

Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for Proteinase-Activated Receptor 2 (PAR₂): binding and visualization
Published May 13, 2008; doi: 10.1124/jpet.108.136432 [Abstract] [PDF]  

Elisabeth Davenas, Agnes Rouleau, Severine Morisset, and Jean-Michel Arrang

Autoregulation of McA-RH7777 hepatoma cell proliferation by histamine H₃ receptors
Published May 12, 2008; doi: 10.1124/jpet.107.135368 [Abstract] [PDF]  

Wai-Pui Tse, Christopher H.K. Cheng, Chun-Tao Che, and Zhi-Xiu Lin

Arsenic Trioxide, Arsenic Pentoxide and Arsenic Iodide Inhibit Human Keratinocyte Proliferation through the Induction of Apoptosis
Published May 1, 2008; doi: 10.1124/jpet.107.134080 [Abstract] [PDF]  

---

CHEMOTHERAPY, ANTIBIOTICS, & GENE THERAPY

Shuqing Lu, Jianmin Yang, Xianmin Song, Shenglan Gong, Hong Zhou, Lieping Guo, Ningxia Song, Xiaochen Bao, Pingping Chen, and Jianmin Wang

Point mutation of the PSMB5 gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line
Published May 23, 2008; doi: 10.1124/jpet.108.138131 [Abstract] [PDF]  

---

ENDOCRINE AND DIABETES

Alexander de Giorgio-Miller, Peter Bungay, Michelle Tutt, Julie Owen, David Goodwin, and Nick Pullen

The Translational Pharmacology Of A Novel, Potent And Selective Non-steroidal Progesterone Receptor Antagonist, PF-02367982
Published July 1, 2008; doi: 10.1124/jpet.108.140467 [Abstract] [PDF] [Data Supplement]  

Yoshikazu Fujimori, Kenji Katsuno, Ikumi Nakashima, Yukiko Ishikawa-Takemura, Hideki Fujikura, and Masayuki Isaji

Remogliflozin etabonate, in a Novel Category of Selective Low-Affinity / High-Capacity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models
Published June 26, 2008; doi: 10.1124/jpet.108.140210 [Abstract] [PDF]  

---

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Shunichi Kajioka, Shinsuke Nakayama, Haruhiko Asano, Narihito Seki, Seiji Naito, and Alison F Brading

Levcromakalim and MgGDP activate small conductance K_ATP channels of Kir6.1/SUR2A in pig detrusor smooth muscle cells: Uncoupling of cAMP signal pathways
Published July 2, 2008; doi: 10.1124/jpet.108.140269 [Abstract] [PDF]  

Le Yu, William KK Wu, Zhi Jie Li, Helen PS Wong, Emily KK Tai, Ya Chun Wu, Hai Tao Li, and Chi Hin Cho

EP2 receptor-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma
Published June 26, 2008; doi: 10.1124/jpet.108.141275 [Abstract] [PDF] [Data Supplement]  

Kazutomo Kita, Kento Takahashi, Yumi Ohashi, Hironori Takasuka, Eitaro Aihara, and Koji Takeuchi

Phosphodiesterase Isozymes Involved in Regulation of HCO₃^- Secretion in Isolated Mouse Stomach In Vitro
Published June 12, 2008; doi: 10.1124/jpet.108.138941 [Abstract] [PDF]  

Melissa A Burmeister, Michael A Ansonoff, John E Pintar, and Daniel R Kapusta

Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension and diuresis are absent in N/OFQ peptide (NOP) receptor knockout (NOP^-/-) mice
Published June 6, 2008; doi: 10.1124/jpet.107.135905 [Abstract] [PDF]  

Kevin S. Thorneloe, Anthony C. Sulpizio, Zuojun Lin, David J. Figueroa, Angela K. Clouse, Gerald P. McCafferty, Tim P. Chendrimada, Erin S. R. Lashinger, Earl A. Gordon, Louise Evans, Blake A. Misajet, Douglas J. DeMarini, Josephine H. Nation, Linda N. Casillas, Robert W. Marquis, Bartholomew J. Votta, Steven A. Sheardown, Xiaoping Xu, David P. Brooks, Nicholas J. Laping, and Timothy D. Westfall

GSK1016790A, a Novel and Potent TRPV4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I
Published May 22, 2008; doi: 10.1124/jpet.108.139295 [Abstract] [PDF] [Data Supplement]  

Yujiro Hayashi, Shino Tsuji, Masahiko Tsujii, Tsutomu Nishida, Shuji Ishii, Hideki Iijima, Toru Nakamura, Hiroshi Eguchi, Eiji Miyoshi, Norio Hayashi, and Sunao Kawano

Topical Implantation of Mesenchymal Stem Cells has Beneficial Effects on Healing of Experimental Colitis in Rats
Published April 30, 2008; doi: 10.1124/jpet.108.137083 [Abstract] [PDF]  

Shunichi Kajioka, Shinsuke Nakayama, Haruhiko Asano, Narihito Seki, Seiji Naito, and Alison F Brading

Levcromakalim and MgGDP activate small conductance K_ATP channels of Kir6.1/SUR2A in pig detrusor smooth muscle cells: Uncoupling of cAMP signal pathways
Published July 2, 2008; doi: 10.1124/jpet.108.140269 [Abstract] [PDF]  

Le Yu, William KK Wu, Zhi Jie Li, Helen PS Wong, Emily KK Tai, Ya Chun Wu, Hai Tao Li, and Chi Hin Cho

EP2 receptor-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma
Published June 26, 2008; doi: 10.1124/jpet.108.141275 [Abstract] [PDF] [Data Supplement]  

Kazutomo Kita, Kento Takahashi, Yumi Ohashi, Hironori Takasuka, Eitaro Aihara, and Koji Takeuchi

Phosphodiesterase Isozymes Involved in Regulation of HCO₃^- Secretion in Isolated Mouse Stomach In Vitro
Published June 12, 2008; doi: 10.1124/jpet.108.138941 [Abstract] [PDF]  

Melissa A Burmeister, Michael A Ansonoff, John E Pintar, and Daniel R Kapusta

Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension and diuresis are absent in N/OFQ peptide (NOP) receptor knockout (NOP^-/-) mice
Published June 6, 2008; doi: 10.1124/jpet.107.135905 [Abstract] [PDF]  

Kevin S. Thorneloe, Anthony C. Sulpizio, Zuojun Lin, David J. Figueroa, Angela K. Clouse, Gerald P. McCafferty, Tim P. Chendrimada, Erin S. R. Lashinger, Earl A. Gordon, Louise Evans, Blake A. Misajet, Douglas J. DeMarini, Josephine H. Nation, Linda N. Casillas, Robert W. Marquis, Bartholomew J. Votta, Steven A. Sheardown, Xiaoping Xu, David P. Brooks, Nicholas J. Laping, and Timothy D. Westfall

GSK1016790A, a Novel and Potent TRPV4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I
Published May 22, 2008; doi: 10.1124/jpet.108.139295 [Abstract] [PDF] [Data Supplement]  

Yujiro Hayashi, Shino Tsuji, Masahiko Tsujii, Tsutomu Nishida, Shuji Ishii, Hideki Iijima, Toru Nakamura, Hiroshi Eguchi, Eiji Miyoshi, Norio Hayashi, and Sunao Kawano

Topical Implantation of Mesenchymal Stem Cells has Beneficial Effects on Healing of Experimental Colitis in Rats
Published April 30, 2008; doi: 10.1124/jpet.108.137083 [Abstract] [PDF]  

---

NEUROPHARMACOLOGY

Eduardo R. Butelman, Szymon Rus, Denise S. Simpson, Angela K.H. Wolf, Thomas E. Prisinzano, and Mary Jeanne Kreek

The effects of herkinorin, the first µ-selective ligand from a salvinorin A- derived scaffold, in a neuroendocrine biomarker assay in non-human primates
Published July 1, 2008; doi: 10.1124/jpet.108.140079 [Abstract] [PDF]  

Yun Liu and Rae R Matsumoto

Alterations in fra-2 and -1 receptor gene and protein expression are associated with the development of cocaine-induced behavioral sensitization: time course and regional distribution studies
Published June 30, 2008; doi: 10.1124/jpet.108.141051 [Abstract] [PDF]  

Trent Volz, Sarah Farnsworth, Shane D. Rowley, Glen R. Hanson, and Annette E. Fleckenstein

METHYLPHENIDATE-INDUCED INCREASES IN VESICULAR DOPAMINE SEQUESTRATION AND DOPAMINE RELEASE IN THE STRIATUM: THE ROLE OF MUSCARINIC AND DOPAMINE D2 RECEPTORS
Published June 30, 2008; doi: 10.1124/jpet.108.139386 [Abstract] [PDF]  

Cheng Xiao, Chunyi Zhou, Kai X Li, Daryl L. Davies, and Jiang Hong Ye

P2 Receptors at GABAergic Synapses on VTA Dopamine Neurons are Targets for Ethanol Action
Published June 26, 2008; doi: 10.1124/jpet.108.139766 [Abstract] [PDF]  

Rosemarie Roeloffs, Alan D Wickenden, Christopher Crean, Steven Werness, Grant McNaughton-Smith, James Stables, James O McNamara, Neil Ghodadra, and Greg C Rigdon

In vivo profile of ICA-27243, a potent and selective KCNQ2/Q3 activator in rodent anticonvulsant models
Published June 24, 2008; doi: 10.1124/jpet.108.137794 [Abstract] [PDF]  

Urszula Baranowska, Manfred Gothert, Radoslaw Rudz, and Barbara Malinowska

Methanandamide allosterically inhibits in vivo the function of peripheral nicotinic acetylcholine receptors containing the 7-subunit
Published June 20, 2008; doi: 10.1124/jpet.108.140863 [Abstract] [PDF]  

Jeffrey M. Witkin, Beth Levant, Agustin Zapata, Rafal Kaminski, and Maciej Gasior

The DopamineD₃/D₂ Agonist R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol [(+)-PD-128,907] Protects Against Acute and Cocaine Kindled Seizures in Mice: Further Evidence for the Involvement of D₃ Receptors
Published June 19, 2008; doi: 10.1124/jpet.108.139212 [Abstract] [PDF]  

Xiao Ru Chen, Valerie C Besson, Tiphaine Beziaud, Michel Plotkine, and Catherine Marchand-Leroux

Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury
Published June 18, 2008; doi: 10.1124/jpet.108.140368 [Abstract] [PDF]  

Wei Hu, Laura Saba, Katherina Kechris, Sanjiv V Bhave, Paula L Hoffman, and Boris Tabakoff

Genomic Insights into Acute Alcohol Tolerance
Published June 11, 2008; doi: 10.1124/jpet.108.137521 [Abstract] [PDF] [Data Supplement]  

Hiroshi Onozuka, Akira Nakajima, Kentaro Matsuzaki, Ryong-Woon Shin, Koichi Ogino, Daisuke Saigusa, Naomi Tetsu, Akihito Yokosuka, Yutaka Sashida, Yoshihiro Mimaki, Tohru Yamakuni, and Yasushi Ohizumi

Nobiletin, a citrus flavonoid, improves memory impairment and A pathology in a transgenic mouse model of Alzheimer's disease
Published June 10, 2008; doi: 10.1124/jpet.108.140293 [Abstract] [PDF]  

Yan Xia, Cheng Z. Wang, Jie Liu, Noelle C. Anastasio, and Kenneth M. Johnson

Lithium Protection of Phencyclidine-induced Neurotoxicity in Developing Brain: The Role PI-3K/Akt and MEK/ERK Signaling Pathways
Published June 10, 2008; doi: 10.1124/jpet.107.133272 [Abstract] [PDF]  

Alan R. Gintzler, Stephen A Schnell, Daya S Gupta, Nai-Jiang Liu, and Martin W Wessendorf

Relationship of spinal dynorphin neurons to delta opioid receptors and estrogen receptor alpha; anatomical basis for ovarian sex steroid opioid antinociception
Published June 9, 2008; doi: 10.1124/jpet.108.139816 [Abstract] [PDF] [Data Supplement]  

Carol S Surowy, Torben R Neelands, Bruce R Bianchi, Steve McGaraughty, Rachid El Kouhen, Ping Han, Katharine L Chu, Heath A McDonald, Melissa Vos, Wende Niforatos, Erol K Bayburt, Arthur Gomtsyan, Chih-Hung Lee, Prisca Honore, James P Sullivan, Michael F Jarvis, and Connie R Faltynek

ABT-102 ((R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea) Blocks Polymodal Activation of TRPV1 Receptors In Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons In Vivo
Published May 30, 2008; doi: 10.1124/jpet.108.138511 [Abstract] [PDF] [Data Supplement]  

Hugh E. Criswell, Zhen Ming, Mary Katherine Kelm, and George R Breese

BRAIN REGIONAL DIFFERENCES IN THE EFFECT OF ETHANOL ON GABA RELEASE FROM PRESYNAPTIC TERMINALS
Published May 23, 2008; doi: 10.1124/jpet.107.135418 [Abstract] [PDF]  

Jere Meredith, Lorin Thompson, Jeremy Toyn, Lawrence Marcin, Donna Barten, Jovita Marcinkeviciene, Lisa Kopcha, Young Kim, Alan Lin, Valerie Guss, Catherine Burton, Lawrence Iben, Craig Polson, Joseph Cantone, Michael Ford, Dieter Drexler, Tracey Fiedler, Kimberley Lentz, James Grace, Janet Kolb, Jason Corsa, Maria Pierdomenico, Kelli Jones, Richard Olson, John Macor, and Charles Albright

P-glycoprotein efflux and other factors limit brain A reduction by BACE1 inhibitors in mice
Published May 22, 2008; doi: 10.1124/jpet.108.138974 [Abstract] [PDF]  

Akio Satow, Shunsuke Maehara, Satoko Ise, Hirohiko Hikichi, Miyuki Fukushima, Gentaroh Suzuki, Toshifumi Kimura, Takeshi Tanaka, Satoru Ito, Hiroshi Kawamoto, and Hisashi Ohta

Pharmacological Effects of the Metabotropic Glutamate Receptor 1 Antagonist Compared with Those of the Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 2/3 Agonist in Rodents: Detailed investigations with a Selective Allosteric mGluR1 Antagonist, FTIDC, (4-[1-(2-fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide)
Published May 22, 2008; doi: 10.1124/jpet.108.138107 [Abstract] [PDF] [Data Supplement]  

Vishakantha Murthy, Thomas J. Martin, Susy Kim, Huw M.L. Davies, and Steven R. Childers

In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain
Published May 20, 2008; doi: 10.1124/jpet.108.138842 [Abstract] [PDF]  

Maia Terashvili, Leon F Tseng, Hsiang-en Wu, Jayashree Narayanan, Lucas M Hart, John R Falck, Phillip F Pratt, and David R Harder

Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of -endorphin and Met-enkephalin in the rat ventrolateral periaqueductal gray
Published May 20, 2008; doi: 10.1124/jpet.108.136739 [Abstract] [PDF]  

Fan Jia, Dev Chandra, Gregg E. Homanics, and Neil L. Harrison

Ethanol Modulates Synaptic and Extrasynaptic GABA_A Receptors in the Thalamus
Published May 13, 2008; doi: 10.1124/jpet.108.139303 [Abstract] [PDF]  

Linda P. Dwoskin, Thomas E. Wooters, Sangeetha P. Sumithran, Kiran B. Siripurapu, B. Matthew Joyce, Paul R. Lockman, Vamshi K. Manda, Joshua T. Ayers, Zhenfa Zhang, Agripina G Deaciuc, J. Michael McIntosh, Peter A. Crooks, and Michael T. Bardo

N,N'-Alkane-diyl-bis-3-picoliniums as Nicotinic Receptor Antagonists: Inhibition of Nicotine-induced Dopamine Release and Hyperactivity
Published May 6, 2008; doi: 10.1124/jpet.108.136630 [Abstract] [PDF]  

Anbrin Masood, Ahmed Nadeem, S Jamal Mustafa, and James M O'Donnell

Reversal of oxidative stress-induced anxiety by inhibition of phosphodiesterase-2 in mice
Published May 2, 2008; doi: 10.1124/jpet.108.137208 [Abstract] [PDF]  

Lisa L Merritt, Billy R. Martin, Carrie Walters, Aron H. Lichtman, and M. Imad Damaj

The endogenous cannabinoid system modulates nicotine reward and dependence
Published May 1, 2008; doi: 10.1124/jpet.108.138321 [Abstract] [PDF]  

Simona Colleoni, Anders A. Jensen, Elisa Landucci, Elena Fumagalli, Paola Conti, Andrea Pinto, Marco De Amici, Domenico E. Pellegrini-Giampietro, Carlo De Micheli, Tiziana Mennini, and Marco Gobbi

Neuroprotective effects of the novel glutamate transporter inhibitor (-)-HIP-A which preferentially inhibits reverse transport (glutamate release) compared to glutamate reuptake
Published May 1, 2008; doi: 10.1124/jpet.107.135251 [Abstract] [PDF]  

---

TOXICOLOGY

Jin Yan and Barbara F. Hales

p38 and JNK Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways Play Distinct Roles in the Response of Organogenesis Stage Embryos to a Teratogen
Published June 24, 2008; doi: 10.1124/jpet.108.139907 [Abstract] [PDF]  

Joseph T Dever and Adnan A Elfarra

L-Methionine Toxicity in Freshly-Isolated Mouse Hepatocytes is Gender-Dependent and Mediated in Part by Transamination
Published June 13, 2008; doi: 10.1124/jpet.108.141044 [Abstract] [PDF]  

Dina Schneider, Maria A Manzan, Robert B Crawford, Weimin Chen, and Norbert E Kaminski

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-mediated Impairment of B cell Differentiation Involves Dysregulation of Paired Box 5 (Pax5) Isoform, Pax5a
Published May 15, 2008; doi: 10.1124/jpet.108.139857 [Abstract] [PDF]  

Emma E Graham, Rachel J Walsh, Charlotte M Hirst, James L Maggs, Scott Martin, Martin J Wild, Ian D Wilson, John R Harding, J. Gerry Kenna, Raimund M Peter, Dominic P Williams, and B. Kevin Park

Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore
Published May 1, 2008; doi: 10.1124/jpet.107.135483 [Abstract] [PDF]  

Zhengyu Cao, Joju George, William H Gerwick, Daniel G Baden, Jon D Rainier, and Thomas F Murray

Influence of lipid soluble gating modifier toxins on sodium influx in neocortical neurons
Published April 30, 2008; doi: 10.1124/jpet.108.138230 [Abstract] [PDF]  

---