Data Supplement
- Supplemental Figures -
1. Synthetic scheme for 4-amino-1-methylpiperidine-2-carboxylic acid (AMPCA).
2. Ability of sialidases to release active TGF-Beta1.
3. Recombinant human NEU3 purified from bacteria.
4. Inhibition of recombinant human NEU3-catalyzed release of active TGF-Beta1 by compounds from Table 1.
5. The effect of sialidases on extracellular accumulation of IL-6.
6. Inhibition by compounds from Table 1 of recombinant human NEU3-induced extracellular accumulation of IL-6 from human PBMCs.
7. NEU3 inhibitors inhibit recombinant mouse NEU3-catalyzed release of active TGF-Beta1.
8. Injections of 2AP, MP, or AMPCA from day 10 after bleomycin treatment had no significant effect on organ weights.
9. AMPCA attenuates bleomycin-induced upregulation of albumin in the BAL fluid at day 21 after bleomycin treatment.
10. Picrosirius red staining of lung cryosections.