Research ArticleDrug Discovery and Translational Medicine
Pharmacological characterization of a novel 5-hydroxybenzothiazolone (5-HOB) derived β2-adrenoceptor agonist with functional selectivity for anabolic effects on skeletal muscle resulting in a wider cardiovascular safety window in preclinical studies
Magdalena Koziczak-Holbro, Dean F Rigel, Berengere Dumotier, David A Sykes, Jeffrey Tsao, Ngoc-Hong Nguyen, Julian Bosch, Marie Jourdain, Ludivine Flotte, Yuichiro Adachi, Michael Kiffe, Moise Azria, Robin A Fairhurst, Steven J Charlton, Brian P Richardson, Estelle Lach-Trifilieff, David J Glass, Thomas Ullrich and Shinji Hatakeyama
Journal of Pharmacology and Experimental Therapeutics February 28, 2019, jpet.118.255307; DOI: https://doi.org/10.1124/jpet.118.255307
Magdalena Koziczak-Holbro
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Dean F Rigel
2 Rigel BioPharma Consulting LLC;
Berengere Dumotier
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
David A Sykes
3 School of Life Sciences, Queen's Medical Centre, University of Nottingham;
Jeffrey Tsao
4 MilliporeSigma;
Ngoc-Hong Nguyen
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Julian Bosch
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Marie Jourdain
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Ludivine Flotte
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Yuichiro Adachi
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Michael Kiffe
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Moise Azria
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Robin A Fairhurst
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Steven J Charlton
3 School of Life Sciences, Queen's Medical Centre, University of Nottingham;
Brian P Richardson
5 RWA Pharma Ltd.
Estelle Lach-Trifilieff
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
David J Glass
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Thomas Ullrich
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Shinji Hatakeyama
1 Novartis Institutes for BioMedical Research, Novartis Pharma AG;
Data Supplement
- Supplemental Data -
3 supplemental tables, 4 figures.