Data Supplement
- Supplemental Figures -
Supplementary Figure 1. Representative current traces illustrating potent and selective block of hNaV1.7 and mNaV1.7 but not rNaV1.7 or hNaV1.5 in a partially inactivated state or hNaV1.7 channels in the resting/closed state by AMG8379 compared to AMG8380 in heterologous cells.
Supplementary Figure 2. Representative current traces illustrating potent and selective block of mNaV1.7, but not hNaV1.2, mNaV1.1, and mNaV1.6, channels by AMG8379 compared to AMG8380 in heterologous cells.