Although most antidepressants suppress serotonin (5-HT) and/or noradrenaline reuptake,
blockade of 5-HT2C receptors and α2-adrenoceptors likewise enhances monoaminergic …

The present studies characterized the functional profile of N-[4-methoxy-3-(4-
methylpiperazin-1-yl) phenyl]-1, 2-dihydro-3-H-benzo [e] indole-3-carboxamide)(S32212), a …

This study aimed to explore the possible mechanisms underlying the antidepressant-like
effect of YL-0919, a novel antidepressant candidate with dual activity as a 5-HT 1A receptor …

SB-243213 (5-methyl-1-[[-2-[(2-methyl-3-pyridyl) oxy]-5-pyridyl] carbamoyl]-6-
trifluoromethylindoline hydrochloride) is a new, selective 5-hydroxytryptamine (5-HT) 2C …

We report here the design, synthesis, and pharmacological properties of a series of
compounds related to tranylcypromine (9), which itself was discovered as a lead compound …

Abstract Deramciclane (EGIS-3886) is a novel anxiolytic agent that binds with high affinity to
5-HT 2A/2C receptors. The interactions of deramciclane with the serotonin 5-HT 2C receptor …

The complex pathophysiology of depression, together with the limits of currently available
antidepressants, has resulted in the continuous quest for alternative therapeutic strategies …

The in vitro and in vivo pharmacological properties of N-(4-fluorophenylmethyl)-N-(1-
methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy) phenylmethyl) carbamide (2 R, 3 R) …

The therapy of depression is challenging and still unsatisfactory despite the presence of
many antidepressant drugs on the market. Consequently, there is a continuous need to …

Despite the importance of 5-hydroxytryptamine (5-HT) 2C (serotonin) receptors in the control
of depressive states, actions of antidepressants at these receptors remain poorly …