Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity

C Hamelink, A Hampson, DA Wink, LE Eiden… - … of Pharmacology and …, 2005 - ASPET
Binge alcohol consumption in the rat induces substantial neurodegeneration in the
hippocampus and entorhinal cortex. Oxidative stress and cytotoxic edema have both been …

A Comparative In Vitro Study of the Neuroprotective Effect Induced by Cannabidiol, Cannabigerol, and Their Respective Acid Forms: Relevance of the 5-HT1A …

C Echeverry, G Prunell, C Narbondo… - Neurotoxicity …, 2021 - Springer
Previous preclinical studies have demonstrated that cannabidiol (CBD) and cannabigerol
(CBG), two non-psychotomimetic phytocannabinoids from Cannabis sativa, induce …

Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro

BS Harvey, KS Ohlsson, JLV Mååg, IF Musgrave… - Neurotoxicology, 2012 - Elsevier
Cannabinoids have been widely reported to have neuroprotective properties in vitro and in
vivo. In this study we compared the effects of CB1 and CB2 receptor-selective ligands, the …

BHT Blocks NF‐κB activation and Ethanol‐Induced Brain Damage

F Crews, K Nixon, D Kim, J Joseph… - Alcoholism: Clinical …, 2006 - Wiley Online Library
Background: Binge ethanol administration causes corticolimbic brain damage that models
alcoholic neurodegeneration. The mechanism of binge ethanol‐induced degeneration is …

Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation

BG Ramírez, C Blázquez, TG Del Pulgar… - Journal of …, 2005 - Soc Neuroscience
Alzheimer9s disease (AD) is characterized by enhanced β-amyloid peptide (βA) deposition
along with glial activation in senile plaques, selective neuronal loss, and cognitive deficits …

Neuroprotection by Δ9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity

M Van der Stelt, WB Veldhuis, PR Bär… - Journal of …, 2001 - Soc Neuroscience
Excitotoxicity is a paradigm used to explain the biochemical events in both acute neuronal
damage and in slowly progressive, neurodegenerative diseases. Here, we show in a …

Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants

AJ Hampson, M Grimaldi… - Proceedings of the …, 1998 - National Acad Sciences
The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat
cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate …

Neuroprotective Antioxidants from Marijuanaa

AJ Hampson, M Grimaldi, M Lolic… - Annals of the New …, 2000 - Wiley Online Library
Cannabidiol and other cannabinoids were examined as neuroprotectants in rat cortical
neuron cultures exposed to toxic levels of the neurotransmitter, glutamate. The psychotropic …

Cannabinoids and brain injury: therapeutic implications

R Mechoulam, D Panikashvili, E Shohami - Trends in molecular medicine, 2002 - cell.com
Mounting in vitro and in vivo data suggest that the endocannabinoids anandamide and 2-
arachidonoyl glycerol, as well as some plant and synthetic cannabinoids, have …

Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures

T Nagayama, AD Sinor, RP Simon, J Chen… - Journal of …, 1999 - Soc Neuroscience
Marijuana and related drugs (cannabinoids) have been proposed as treatments for a
widening spectrum of medical disorders. R (+)-[2, 3-dihydro-5-methyl-3-[(morpholinyl) …