[PDF][PDF] Prostaglandins and ulcer healing

SJ Konturek, PC Konturek… - Journal of physiology and …, 2005 - jpp.krakow.pl
Exogenous prostaglandins (PG) applied in small gastroprotective doses fail to affect healing
of gastro-duodenal ulcers but accelerate the healing when used in larger gastric inhibitory …

[PDF][PDF] Gastrointestinal safety of novel nonsteroidal antiinflammatory drugs: selective COX-2 inhibitors and beyond

G Coruzzi, N Venturi, S Spaggiari - Acta Biomedica-Ateneo …, 2007 - researchgate.net
Nonsteroidal antiinflammatory drugs (NSAIDs) are frequently associated with adverse
reactions, related to inhibition of cyclooxygenase (COX) in tissues where prostaglandins …

Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation

M Jainu, CSS Devi - Journal of ethnopharmacology, 2006 - Elsevier
Solanum nigrum, an herbal plant which is recommended in ayurveda for the management of
gastric ulcers. Therefore, the purpose of the study was to investigate the antiulcer effect of …

Antiulcer and antioxidant activities of a new steroid from Morus alba

A Ahmad, G Gupta, M Afzal, I Kazmi, F Anwar - Life sciences, 2013 - Elsevier
AIMS: Morus alba is a plant that is well known for its medicinal properties. In Asian countries,
it is traditionally used for anti-inflammatory, hypoglycemic, hypolipidemic and antioxidant …

[BOOK][B] Toxicologic pathology: nonclinical safety assessment

PS Sahota, JA Popp, JF Hardisty, C Gopinath - 2013 - books.google.com
As drug development shifts over time to address unmet medical needs and more targeted
therapies are developed, previously unseen pharmacological or off-target effects may occur …

Pathophysiology of gastric ulcer development and healing: molecular mechanisms and novel therapeutic options

M Fornai, L Antonioli, C Rocchina, T Marco… - Peptic ulcer …, 2011 - books.google.com
The stomach plays a pivotal role in the digestion of foods that we eat. With the exception of
rare cases, this organ can resist to a large variety of noxious factors, including hydrochloric …

Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment …

M Fornai, R Colucci, L Antonioli, O Awwad… - Pharmacological …, 2011 - Elsevier
Proton pump inhibitors promote ulcer repair in nonsteroidal anti-inflammatory drug (NSAID)-
treated patients with ongoing NSAID-induced gastric toxicity, although the underlying …

[HTML][HTML] Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway

N Yamagishi, Y Yamamoto, T Nishi, T Ito, Y Kanai - Plos one, 2023 - journals.plos.org
Lansoprazole, a proton pump inhibitor, can exert antioxidant effects through the induction of
the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, independently of the inhibition …

Probiotics regulate the expression of COX-2 in intestinal epithelial cells

JM Otte, R Mahjurian-Namari, S Brand… - Nutrition and …, 2008 - Taylor & Francis
Cyclooxygenase-2 (COX) 2 promotes intestinal wound healing but elicits also
proinflammatory effects and has been implicated in colorectal carcinogenesis. Thus, a …

Beyond gastric acid reduction: proton pump inhibitors induce heme oxygenase-1 in gastric and endothelial cells

JC Becker, N Grosser, C Waltke, S Schulz… - Biochemical and …, 2006 - Elsevier
Proton pump inhibitors (PPIs) have been demonstrated to prevent gastric mucosal injury by
mechanisms independent of acid inhibition. Here we demonstrate that both omeprazole and …