The lack of a common exchange format for mathematical models in pharmacometrics has
been a long‐standing problem. Such a format has the potential to increase productivity and …

Oncolytic viruses (OVs) represent a potential therapeutic strategy in cancer treatment. However,
there is currently a lack of comprehensive quantitative models characterizing clinical OV …

V937 is an investigational novel oncolytic non-genetically modified Kuykendall strain of
Coxsackievirus A21 which is in clinical development for the treatment of advanced solid tumor …

Objectives Patients with congenital adrenal hyperplasia (CAH) require lifelong replacement
therapy with glucocorticoids. Optimizing hydrocortisone therapy is challenging, since there …

Monoclonal antibodies (mAbs) constitute a therapeutically and economically important drug
class with increasing use in both adult and paediatric patients. The rather complex …

Total tumor size (TS) metrics used in TS models in oncology do not consider tumor heterogeneity,
which could help to better predict drug efficacy. We analyzed individual target lesions (…

Paclitaxel is a commonly used cytotoxic anticancer drug with potentially life-threatening toxicity
at therapeutic doses and high interindividual pharmacokinetic variability. Thus, drug and …

Immunotherapy is a growing therapeutic strategy in oncology based on the stimulation of
innate and adaptive immune systems to induce the death of tumour cells. In this paper, we …

Since gene therapy started over 20 years ago, more than one-thousand clinical trials have
been carried out. Nonviral vectors present interesting properties for their clinical application, …

… Parra-Guillen b , Elke Hammer c , Martin Michaelis d , Jindrich Cinatl Jr. e , Uwe Völker c
, Holger Fröhlich f , Charlotte Kloft b 2 , Christoph A. Ritter a 2 …