User profiles for Y. von Grabowiecki
Yannick von GrabowieckiMRC Toxicology Unit, Leicester Verified email at ygrabo.com Cited by 106 |
Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63
Y von Grabowiecki, P Abreu, O Blanchard, L Palamiuc… - Elife, 2016 - elifesciences.org
… von Grabowiecki et al. have now identified p63 as a protein that contributes to muscle
wasting in ALS. The production of p63 in degenerated muscles increases as the disease …
wasting in ALS. The production of p63 in degenerated muscles increases as the disease …
[HTML][HTML] Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane
V Phatak, Y von Grabowiecki, J Janus, L Officer… - Cell death & …, 2021 - nature.com
TP53 is the most frequently mutated gene in cancers. Mutations lead to loss of p53 expression
or expression of a mutant protein. Mutant p53 proteins commonly lose wild-type function, …
or expression of a mutant protein. Mutant p53 proteins commonly lose wild-type function, …
Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy
Y von Grabowiecki, C Licona, L Palamiuc… - … of Pharmacology and …, 2015 - ASPET
Muscular atrophy, a physiopathologic process associated with severe human diseases
such as amyotrophic lateral sclerosis (ALS) or cancer, has been linked to reactive oxygen …
such as amyotrophic lateral sclerosis (ALS) or cancer, has been linked to reactive oxygen …
[HTML][HTML] Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons
S Benosman, X Meng, Y Von Grabowiecki… - Journal of Biological …, 2011 - ASBMB
Genetic ablations of p73 have shown its implication in the development of the nervous system.
However, the relative contribution of ΔNp73 and TAp73 isoforms in neuronal functions is …
However, the relative contribution of ΔNp73 and TAp73 isoforms in neuronal functions is …
[HTML][HTML] iRFP (near-infrared fluorescent protein) imaging of subcutaneous and deep tissue tumours in mice highlights differences between imaging platforms
Background In vivo imaging using fluorescence is used in cancer biology for the detection,
measurement and monitoring of tumours. This can be achieved with the expression of …
measurement and monitoring of tumours. This can be achieved with the expression of …
[HTML][HTML] Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer
Y von Grabowiecki, V Phatak, L Aschauer… - Frontiers in …, 2021 - frontiersin.org
Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking
of various molecules throughout the endocytic compartments of the cell. The consequence of …
of various molecules throughout the endocytic compartments of the cell. The consequence of …
The p53 family of transcription factors in muscular atrophy: involvements in amyotrophic lateral sclerosis and cachexia
Y von Grabowiecki - 2013 - theses.hal.science
… Yannick von Grabowiecki … Yannick von Grabowiecki. The p53 family of transcription factors
in muscular atrophy: involvements in amyotrophic lateral sclerosis and cachexia. Genomics [q-…
in muscular atrophy: involvements in amyotrophic lateral sclerosis and cachexia. Genomics [q-…
Copper levels and the p53 protein: A delicate balance
P Muller, Y Grabowiecki, C Hall - Cancer Research, 2019 - AACR
The tumor suppressor p53 is mutated in 50% of all cancers and in about 90% of small lung
cancers. Mutations lead to loss of p53 expression or the expression of mutant p53 proteins. …
cancers. Mutations lead to loss of p53 expression or the expression of mutant p53 proteins. …
[HTML][HTML] Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
Q Ran, Y Yu, X Fu, Y Wen - Neural Regeneration Research, 2015 - journals.lww.com
The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation,
but it remains unclear whether it is involved in vascular repair by endothelial progenitor …
but it remains unclear whether it is involved in vascular repair by endothelial progenitor …
Circus-mobility: The value of a circus laboratory at school
M Valentini, A Cesauri, R Schembri, A Federici - 2020 - rua.ua.es
The circus has always fascinated children due to its magic, imaginary and creativity. In this
work, we analyse international research which emphasises the value of the discipline of the …
work, we analyse international research which emphasises the value of the discipline of the …