Aldosterone may play a pivotal role in the pathophysiology of heart failure. To elucidate the
beneficial cardioprotective mechanism of eplerenone, a novel selective aldosterone blocker, …

… the cardiovascular remodeling was improved by treatment with Y-27632. Recently, we have
showed that expression of eNOS was stimulated by administration of Y-27632 in the DS rat. …

Vascular cell adhesion molecule-1 (VCAM-1) and reactive oxygen species play critical roles
in early atherogenesis, and nitric oxide (NO) is an important regulator of the cardiovascular …

… II plus Y-27632 or Ang II plus candesartan. Ang II-induced PAI-1 mRNA up-regulation in the
left ventricle was inhibited by Y-… were suppressed by Y-27632 and candesartan. In contrast, …

Nicorandil is an adenosine triphosphate sensitive K (K-ATP) channel opener and a nitric oxide
donor. K-ATP channels and nitric oxide are important factors in ischemic preconditioning, …

To elucidate the molecular mechanisms of the cardioprotective effect of angiotensin-converting
enzyme (ACE) inhibitors, we evaluated whether the effect of quinapril involved in …

Adrenomedullin (AM) has vasodilatory, diuretic and natriuretic actions. Two molecular forms
of AM circulate in human plasma: an active, mature form of AM (AM-m) and an intermediate, …

Objective Endothelium-dependent vasodilation is attenuated in humans and experimental
hypertension models, and this phenomenon may be largely due to decreased release or …

We evaluated the effects of cilnidipine, a long-acting Ca 2+ channel antagonist, on
endothelial nitric oxide synthase (eNOS), preproendothelin-1 and endothelin ETA receptor …

Endothelin and growth factors such as transforming growth factor (TGF)-β1 are important
regulators of the cardiovascular system. Although increased production of endothelin-1 (ET-1) …