Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma
K Kumagai, I Ohno, S Okada, Y Ohkawara… - The Journal of …, 1999 - journals.aai.org
Although matrix metalloproteinases (MMPs) have been reported to play crucial roles in the
migration of inflammatory cells through basement membrane components in vitro, the role of …
migration of inflammatory cells through basement membrane components in vitro, the role of …
Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine whose
expression is increased in numerous respiratory diseases, particularly in asthma. However, …
expression is increased in numerous respiratory diseases, particularly in asthma. However, …
CD40 expression by human peripheral blood eosinophils.
Y Ohkawara, KG Lim, Z Xing, M Glibetic… - The Journal of …, 1996 - Am Soc Clin Investig
In this study, we have investigated CD40 expression in human peripheral blood eosinophils
and in human chronically inflamed nasal tissues, ie, nasal polyps. We show by both reverse …
and in human chronically inflamed nasal tissues, ie, nasal polyps. We show by both reverse …
Activation and transforming growth factor-β production in eosinophils by hyaluronan
Y Ohkawara, G Tamura, T Iwasaki… - American journal of …, 2000 - atsjournals.org
To investigate whether extracellular matrix glycosaminoglycan hyaluronan (HA) modulates
eosinophil activation and transforming growth factor (TGF)- β production by eosinophils, …
eosinophil activation and transforming growth factor (TGF)- β production by eosinophils, …
Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation.
Y Ohkawara, XF Lei, MR Stämpfli… - American journal of …, 1997 - atsjournals.org
Selective accumulation of eosinophils and activated CD4+ cells is now considered a central
event in the pathogenesis of asthma, and this process is thought to be mediated by a …
event in the pathogenesis of asthma, and this process is thought to be mediated by a …
Human lung mast cells and pulmonary macrophages produce tumor necrosis factor-a in sensitized lung tissue after 19B receptor triggering
Y Ohkawara, K Yamauchi, Y Tanno… - Am J Respir Cell Mol …, 1992 - atsjournals.org
Materials and Methods Preparation of Lung Tissue Normal regions of human lung tissue,
which was surgically excised from 15patients with lung cancer, were chopped into …
which was surgically excised from 15patients with lung cancer, were chopped into …
In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with air flow limitation: in vivo evidence of VCAM-1/VLA-4 interaction in selective …
Y Ohkawara, K Yamauchi, N Maruyama… - American journal of …, 1995 - atsjournals.org
Eosinophils play a critical role in the pathogenesis of bronchial asthma by releasing various
mediators. To understand the mechanisms of eosinophil migration to the site of inflammation…
mediators. To understand the mechanisms of eosinophil migration to the site of inflammation…
TNF-alpha mRNA expression in diaphragm muscle after endotoxin administration.
C Shindoh, W Hida, Y Ohkawara… - American journal of …, 1995 - atsjournals.org
We studied gene expression and production of TNF-alpha in the diaphragm tissue and changes
of muscle contractile properties after endotoxin injection (Escherichia coli, 20 mg/kg) in …
of muscle contractile properties after endotoxin injection (Escherichia coli, 20 mg/kg) in …
Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway
…, H Suzuki, H Nakazawa, Y Ohkawara… - … of Physiology-Lung …, 1994 - journals.physiology.org
In mammals, histamine is inactivated principally by two enzymes: histamine N-methyltransferase
(HMT; EC 2.1.1.8) and diamine oxidase (DAO; EC 1.4.3.6.). The cDNA clone of human …
(HMT; EC 2.1.1.8) and diamine oxidase (DAO; EC 1.4.3.6.). The cDNA clone of human …
Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia
Interleukin-10 (IL-10) is a potent anti-inflammatory/immune cytokine and has received
growing attention for its therapeutic potential. To aid therapeutic studies of IL-10 in vivo, a …
growing attention for its therapeutic potential. To aid therapeutic studies of IL-10 in vivo, a …