Asymmetric synthesis has witnessed a burgeoning activity in the discovery, development, and
application of numerous methods for the creation of stereogenic centers with high levels of …

… Bennani, Gerard A. Crispino, Jens Hartung, Kyu-Sung Jeong, Hoi-Lun Kwong, Kouhei
Morikawa, Zhi-Min Wang, Daqiang Xu, and Xiu-Lian Zhang … (h) Ogino, Y.; Chen, H.; …

This review brings to the forefront key synthetic modifications on natural products (NPs) that
have yielded successful drugs. The emphasis is placed on the power of targeted chemical …

Pharmaceutical companies must find a better way to increase their output of truly new drugs
for the benefit of patients and for their business survival. Here, I highlight a general …

Acute pharmacological blockade of central histamine H 3 receptors (H 3 Rs) enhances
arousal/attention in rodents. However, there is little information available for other behavioral …

In our effort to develop agents for the treatment of influenza, a phenotypic screening approach
utilizing a cell protection assay identified a series of azaindole based inhibitors of the cap-…

… We assume that X × Y is drawn from an unknown joint probability distribution D and that
we observe them through a finite training sample (also called the learning sample) S = {(xi,yi)}m …

Telaprevir 2 (VX-950), an inhibitor of the hepatitis C virus (HCV a ) NS3-4A protease, is in
phase 3 clinical trials. One of the major metabolites of 2 is its P1-(R)-diastereoisomer, 3 (VRT-…

Candida albicans and Cryptococcus neoformans cause both superficial and disseminated
infections in humans. Current antifungal therapies for deep-seated infections are limited to …

… We note that depending on the application, both X and Y can be defined in … Y and assuming
that there is an unknown joint probability distribution D defined on their product space X × Y…