A new perspective in the field of cardiac safety testing through the comprehensive in vitro proarrhythmia assay paradigm

…, T Colatsky, K Correll, W Crumb… - Journal of …, 2016 - journals.sagepub.com
For the past decade, cardiac safety screening to evaluate the propensity of drugs to produce
QT interval prolongation and Torsades de Pointes (TdP) arrhythmia has been conducted …

Drugs that prolong QT interval as an unwanted effect: assessing their likelihood of inducing hazardous cardiac dysrhythmias

…, M Mestre, JM Guillon, W Crumb - Expert opinion on …, 2000 - Taylor & Francis
Medicinal products that, as an unwanted effect, prolong the QT interval of the electrocardiogram
(ECG) can trigger episodes of polymorphic ventricular dysrhythmias, called torsades de …

QT interval prolongation by non-cardiovascular drugs: issues and solutions for novel drug development

W Crumb, I Cavero - Pharmaceutical Science & Technology Today, 1999 - Elsevier
In 1997, the Committee for Proprietary Medicinal Products (CPMP) issued a document
concerning the potential of non-cardiovascular drugs to cause prolongation of the QT interval of …

The selective sphingosine 1‐phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species‐specific effects on heart rate

…, A Gardin, N Wang, WJ Crumb Jr… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE BAF312 is a next‐generation sphingosine 1‐phosphate (S1P)
receptor modulator, selective for S1P 1 and S1P 5 receptors. S1P 1 receptors are …

Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

S Ekins, WJ Crumb, RD Sarazan, JH Wikel… - … of Pharmacology and …, 2002 - ASPET
… The General hERG model was validated using the combined IC 50 values generated in
the present study as well as a previous study (Crumb et al., 2001), which were fit to the …

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

WJ Crumb Jr, J Vicente, L Johannesen… - … of pharmacological and …, 2016 - Elsevier
Introduction The Comprehensive in vitro Proarrhythmia Assay (CiPA) is intended to address
the misidentification of drug-associated torsade de pointes risk based solely on hERG and …

Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias

…, V Zamora, G Smith, WJ Crumb… - Toxicological …, 2017 - academic.oup.com
… calcium current (ICaL), encoded by Cav1.2, and late sodium current (late-INa), encoded by
Nav1.5, which are the three channels primarily affected by the drugs in this study (Crumb et al…

A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias

…, S Karpinski, CH Li, L Hu, XJ Li, W Crumb… - … of Pharmacology and …, 2013 - ASPET
Inhibition of cardiac late sodium current (late I Na ) is a strategy to suppress arrhythmias and
sodium-dependent calcium overload associated with myocardial ischemia and heart failure. …

Properties of concrete pedestrian block mixed with crumb rubber

P Sukontasukkul, C Chaikaew - Construction and Building Materials, 2006 - Elsevier
… In this study, the use of crumb rubber to replace coarse and fine aggregates … crumb rubber
can make concrete blocks more flexible and thus, provide softness to the surface. The crumb

Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative

…, J Kramer, C Wu, WJ Crumb Jr… - Clinical …, 2019 - Wiley Online Library
The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are
sensitive but not specific for predicting which drugs are pro‐arrhythmic. In response, the …