Background Patients with familial adenomatous polyposis have a nearly 100 percent risk of
colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal …

Background and Methods. Patients with acute promyelocytic leukemia have a characteristic
(15;17) translocation, with a breakpoint on chromosome 17 in the region of the retinoic acid …

Our 10-year translational study of the oral premalignant lesion (OPL) model has advanced
the basic understanding of carcinogenesis. Although retinoids have established activity in this …

Background and Purpose: Genetic damage has been identified at multiple chromosomal sites
(ie, loci) in lung cancer cells. We questioned whether similar damage could be detected in …

We have utilized antibody probes to examine the expression of DNA topoisomerases I and
II and chromosome scaffold protein Sc-2 in normal and transformed cells. Neither …

… and Hittelman, WN Detection of chromosomes 7 and 17 aneuploidies during multistep
carcinogenesis of head and neck cancer by in situ hybridization. Cancer Res., 53: 2874—2883,…

Cervical cancer is the second most common malignancy in women worldwide and remains
a significant health problem for women, especially minority women in the United States. …

The etiology of the majority of human breast cancers is unknown; however, oxidative stress
and lipid peroxidation have been suggested to play a role in breast carcinogenesis. To …

Epithelial tumors develop through a multistep process driven by genomic instability frequently
associated with etiologic agents such as prolonged tobacco smoke exposure or human …

… Voravud, N., Shin, DM, Ro, JY, Lee, JS, Hong, WK, and Hittelman, WN Increased polysomies
of … Shin, DM, Voravud, N., Ro, JY, Lee, JS, Hong, WK, and Hittelman, WN Sequential …