Neurotrophins and synaptic plasticity in the mammalian spinal cord

…, JB Munson, VL Arvanian - The Journal of …, 2001 - Wiley Online Library
The pathway mediating the monosynaptic stretch reflex has served as an important model
system for studies of plasticity in the spinal cord. Its usefulness is extended by evidence that …

Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral …

…, LM Mendell, JW Fawcett, VL Arvanian - Journal of …, 2011 - Soc Neuroscience
Elevating spinal levels of neurotrophin NT-3 (NT3) while increasing expression of the NR2D
subunit of the NMDA receptor using a HSV viral construct promotes formation of novel …

Chronic spinal hemisection in rats induces a progressive decline in transmission in uninjured fibers to motoneurons

VL Arvanian, L Schnell, L Lou, R Golshani… - Experimental …, 2009 - Elsevier
Although most spinal cord injuries are anatomically incomplete, only limited functional
recovery has been observed in people and rats with partial lesions. To address why surviving …

Role of chondroitin sulfate proteoglycans in axonal conduction in Mammalian spinal cord

…, JW Fawcett, LM Mendell, VL Arvanian - Journal of …, 2010 - Soc Neuroscience
Chronic unilateral hemisection (HX) of the adult rat spinal cord diminishes conduction through
intact fibers in the ventrolateral funiculus (VLF) contralateral to HX. This is associated with …

Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats

…, V Alessi, L Schnell, J Levine, VL Arvanian - Journal of …, 2013 - Soc Neuroscience
NG2 belongs to the family of chondroitin sulfate proteoglycans that are upregulated after
spinal cord injury (SCI) and are major inhibitory factors restricting the growth of fibers after SCI. …

Transduction efficiency of neurons and glial cells by AAV-1,-5,-9,-rh10 and-hu11 serotypes in rat spinal cord following contusion injury

…, V Singh, AS Hunanyan, JM Levine, VL Arvanian - Gene therapy, 2014 - nature.com
Adeno-associated viruses (AAVs) are a promising system for therapeutic gene delivery to
neurons in a number of neurodegenerative conditions including spinal cord injuries (SCIs). …

Combined delivery of Nogo‐A antibody, neurotrophin‐3 and the NMDA‐NR2d subunit establishes a functional 'detour'in the hemisected spinal cord

…, ME Schwab, LM Mendell, VL Arvanian - European Journal of …, 2011 - Wiley Online Library
To encourage re‐establishment of functional innervation of ipsilateral lumbar motoneurons
by descending fibers after an intervening lateral thoracic (T10) hemisection (Hx), we treated …

AAV vector mediated delivery of NG2 function neutralizing antibody and neurotrophin NT-3 improves synaptic transmission, locomotion, and urinary tract function after …

…, WF Collins, J Levine, VL Arvanian - Journal of …, 2023 - Soc Neuroscience
NG2 is a structurally unique transmembrane chondroitin sulfate proteoglycan (CSPG). Its role
in damaged spinal cord is dual. NG2 is considered one of key inhibitory factors restricting …

Spinal electro-magnetic stimulation combined with transgene delivery of neurotrophin NT-3 and exercise: novel combination therapy for spinal contusion injury

…, AS Hunanyan, SA Sisto, VL Arvanian - Journal of …, 2015 - journals.physiology.org
Our recent terminal experiments revealed that administration of a single train of repetitive
spinal electromagnetic stimulation (sEMS; 35 min) enhanced synaptic plasticity in spinal …

Combination of chondroitinase ABC and AAV-NT3 promotes neural plasticity at descending spinal pathways after thoracic contusion in rats

…, HA Petrosyan, V Alessi, VL Arvanian - Journal of …, 2013 - journals.physiology.org
Transmission through descending pathways to lumbar motoneurons, although important for
voluntary walking in humans and rats, has not been fully understood at the cellular level in …