Non-fucosylated therapeutic antibodies: the next generation of therapeutic antibodies

…, R Nakano, H Imai-Nishiya, A Okazaki, T Shinkawa… - Cytotechnology, 2007 - Springer
Therapeutic antibody IgG1 has two N-linked oligosaccharide chains bound to the Fc region.
The oligosaccharides are of the complex biantennary type, composed of a trimannosyl core …

[HTML][HTML] The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical …

T Shinkawa, K Nakamura, N Yamane… - Journal of Biological …, 2003 - ASBMB
… The purified humanized anti-hIL-5R IgG1 antibodies, KM8399 (YB2/0-produced) and KM8404
(CHO-produced), were compared for their ability to induce ADCC against a murine T cell …

Measurement of neutrino-proton and antineutrino-proton elastic scattering

…, D Cutts, JS Hoftun, M Diwan, RE Lanou, T Shinkawa… - Physical Review D, 1987 - APS
Measurements of the semileptonic weak-neutral-current reactions ν μ p→ ν μ p and ν μ p→
ν μ p are presented. The experiment was performed using a 170-metric-ton high-resolution …

Study of the decay in the momentum region

…, G Redlinger, T Sato, T Sekiguchi, T Shinkawa… - Physical Review D, 2009 - APS
Experiment E949 at Brookhaven National Laboratory has observed three new events
consistent with the decay K+→ π+ ν ν in the pion momentum region 140< P π< 199 MeV/c in an …

Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins

H Kaji, H Saito, Y Yamauchi, T Shinkawa… - Nature …, 2003 - nature.com
We describe here a strategy for the large-scale identification of N-glycosylated proteins from
a complex biological sample. The approach, termed isotope-coded glycosylation-site-…

New Measurement of the Branching Ratio

…, G Redlinger, T Sato, T Sekiguchi, T Shinkawa… - Physical review …, 2008 - APS
Three events for the decay K+→ π+ ν ν have been observed in the pion momentum region
below the K+→ π+ π 0 peak, 140< P π< 199 MeV/c, with an estimated background of 0.93±…

Experimental study of the decay

…, T Sato, M Sekimoto, T Shimogawa, T Shinkawa… - Physical Review D, 2010 - APS
… Fujioka,2 YB Hsiung,4 T. Inagaki,6,7 S. Ishibashi,2 N. … Shinkawa,12 Y. Stepanenko,3 Y.
Sugaya,8 A. … The neutral beam line consisted of two dipole magnets (D1, D2) to sweep …

[HTML][HTML] Heterogeneity of cancer-associated fibroblasts and the tumor immune microenvironment in pancreatic cancer

T Shinkawa, K Ohuchida, M Nakamura - Cancers, 2022 - mdpi.com
… In addition, ecm-myCAF and TGF-β-myCAF subgroups were enriched in tumors with a
high proportion of PD-1+CTLA4+TIGIT+ CD4+ T lymphocytes and a low proportion of CD8+ T

Improved Measurement of the Branching Ratio

…, G Redlinger, T Sato, T Sekiguchi, T Shinkawa… - Physical review …, 2004 - APS
An additional event near the upper kinematic limit for K+→ π+ ν ν has been observed by
experiment E949 at Brookhaven National Laboratory. Combining previously reported and new …

Further Evidence for the Decay

…, T Sato, K Shimada, T Shimoyama, T Shinkawa… - Physical review …, 2002 - APS
Additional evidence for the rare kaon decay K+→ π+ ν ν has been found in a new data set
with comparable sensitivity to the previously reported result. One new event was observed in …