Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function

…, GE Bentley, G Bedecarrats, T Osugi, T Ubuka… - Frontiers in …, 2010 - Elsevier
Identification of novel neurohormones that regulate the reproductive axis is essential for the
progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) …

Discovery and evolutionary history of gonadotrophin‐inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction

…, GE Bentley, LJ Kriegsfeld, T Osugi… - Journal of …, 2010 - Wiley Online Library
Gonadotrophin‐releasing hormone (GnRH) is the primary hypothalamic factor responsible
for the control of gonadotrophin secretion in vertebrates. However, within the last decade, two …

The general and comparative biology of gonadotropin-inhibitory hormone (GnIH)

…, GE Bentley, T Ubuka, E Saigoh, H Yin, T Osugi… - General and …, 2007 - Elsevier
The decapeptide gonadotropin-releasing hormone (GnRH) is the primary factor responsible
for the hypothalamic control of gonadotropin secretion. Gonadal sex steroids and inhibin …

Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells

S Ueno, G Weidinger, T Osugi… - Proceedings of the …, 2007 - National Acad Sciences
Understanding pathways controlling cardiac development may offer insights that are useful
for stem cell-based cardiac repair. Developmental studies indicate that the Wnt/β-catenin …

Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced …

…, E Tone, M Funamoto, T Osugi… - Proceedings of the …, 2000 - National Acad Sciences
The signal transducer and activator of transcription (STAT) 3, a transcriptional factor downstream
of several cytokines, is activated by Janus kinase families and plays a pivotal role in …

Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats

…, T Iwasa, T Yasui, M Irahara, T Osugi… - Journal of …, 2008 - joe.bioscientifica.com
Gonadotropin-inhibitory hormone (GnIH), a newly discovered hypothalamic RFamide peptide,
inhibits reproductive activity by decreasing gonadotropin synthesis and release in birds. …

[HTML][HTML] Endogenous Wnt/β-catenin signaling is required for cardiac differentiation in human embryonic stem cells

SL Paige, T Osugi, OK Afanasiev, L Pabon… - PloS one, 2010 - journals.plos.org
Background Wnt/β-catenin signaling is an important regulator of differentiation and morphogenesis
that can also control stem cell fates. Our group has developed an efficient protocol to …

Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and-II neurons in European starling brain

…, S Kim, Y Huang, J Reid, J Jiang, T Osugi… - …, 2008 - academic.oup.com
… of 1:1000 in 0.4% PBS-T. Three subsequent washes in 0.2% PBS-T were followed by
incubation for 1 h in biotinylated goat antirabbit IgG (1:1000 in 0.2% PBS-T). Sections were then …

[HTML][HTML] Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis

T Ubuka, K Morgan, AJ Pawson, T Osugi… - PloS one, 2009 - journals.plos.org
… the sections in 2% normal goat serum in PBS-T, sections were incubated overnight at 4C in
the white-crowned sparrow GnIH antibody in PBS-T at a concentration of 1∶5000. The next …

Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation …

…, Y Fujio, M Funamoto, MI Darville, DL Eizirik, T Osugi… - Circulation, 2001 - Am Heart Assoc
Background Mice with cardiac-specific overexpression of signal transducer and activator of
transcription 3 (STAT3) are resistant to doxorubicin-induced damage. The STAT3 signal may …