The mechanisms underlying the circadian rhythm of the toxicity induced by irinotecan
hydrochloride (CPT-11; 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) were …

Influence of hydroxyurea (HU) on the antitumor effect of irinotecan hydrochloride (CPT-11)
was investigated in ICR male mice transplanted with sarcoma 180 cells (S-180). A single …

In this article, we report a new method of cell cycle stage typing using a microcapillary
electrophoresis (µCE) chip. Cell electrophoretic mobility (EPM) is considered to be useful …

Cell physiology is regulated by a 24-hour clock, consisting of interconnected molecular
loops, involving at least nine genes. The cellular clock is coordinated by the suprachiasmatic …

Purpose. To evaluate the activity and tolerability of salvage chronomodulated chemotherapy
combining irinotecan (I), 5-fluorouracil/leucovorin (5-FU/LV), and oxaliplatin (O) (chronoIFLO…

To identify whether Topoisomerase I (TopoI) has autonomous circadian rhythms regulated by
clock genes, we tested mouse TopoI (mTopoI) promoter oscillation in NIH3T3 cells using a …

Power of epidemiologic studies can be studied via simulation, but simulations can require
substantial computational effort and time. We describe a method for estimating power in …

… Here, we didn’t follow the approach of increasing the number of drugs, but instead
increased the doses of the two or three drugs we gave. As I showed, this could be done only at …

… Student’s t-test was used for two independent groups. The 5 % level of probability was
considered to be significant. … P0.01 when compared between two groups using Student’s t-test. …

Purpose: Clinically, diarrhea is the major dose-limiting toxicity of irinotecan hydrochloride (CPT-11).
Using a rat model, we attempted to decrease the incidence of delayed-onset …