Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase

KY Lin, A Ito, T Asagami, PS Tsao, S Adimoolam… - Circulation, 2002 - Am Heart Assoc
Background— An endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine
(ADMA), is elevated in patients with type 2 diabetes mellitus (DM). This study explored the …

Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress

…, H Matsushita, W Li, AJ Glassford, T Asagami… - Circulation …, 2001 - Am Heart Assoc
… Dr Asagami has been awarded a postdoctoral fellowship from the American Heart Association,
Western States Affiliate. The authors would also like to thank Dr Gerald M. Reaven for his …

Apelin is necessary for the maintenance of insulin sensitivity

…, AC Deng, J Azuma, T Asagami… - American journal …, 2010 - journals.physiology.org
The recently discovered peptide apelin is known to be involved in the maintenance of
insulin sensitivity. However, questions persist regarding its precise role in the chronic setting. …

Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes

T Asagami, F Abbasi, M Stuelinger… - Metabolism …, 2002 - metabolismjournal.com
This study was initiated to see if plasma asymmetric dimethylarginine (ADMA) concentrations
decreased in hyperglycemic patients with type 2 diabetes following metformin treatment, …

[HTML][HTML] Hyperglycemia limits experimental aortic aneurysm progression

…, MM Dua, JJ Yeung, GM Schultz, T Asagami… - Journal of vascular …, 2010 - Elsevier
… Determination of significance between two groups of continuous variables was performed
using the t-test; adjustments for multiple comparisons were performed using one-way analysis …

Creation of murine experimental abdominal aortic aneurysms with elastase

J Azuma, T Asagami, R Dalman, PS Tsao - JoVE (Journal of Visualized …, 2009 - jove.com
Transient intraluminal infusion of porcine pancreatic elastase into the infrarenal segment of
the abdominal aorta is the most widely used animal model of abdominal aortic aneurysm (…

Kinins contribute to the improvement of insulin sensitivity during treatment with angiotensin converting enzyme inhibitor.

…, T Ishii, A Takahashi, L Furukawa, T Asagami… - …, 1994 - Am Heart Assoc
… Gohlke P, Mattfeldt T, Mall G, Lamberty V, Unger T. Chronic low dose converting enzyme
inhibitor … Bao G, Gohlke P, Qadri F, Unger T. Chronic kinin receptor blockade attenuates the …

Effect of Microbial trasglutaminase on the quality of Frozen Surimi Made from Various Kinds of Fish Species

T Asagami, M Ogiwara, A Wakameda… - Fisheries science, 1995 - jstage.jst.go.jp
The effects of microbial transglutaminase (MTGase) on fish muscles of seven kinds of fish-species
were studied to increase the basic knowledge of the preparation of the high quality …

[HTML][HTML] Selective glucocorticoid receptor (GR-II) antagonist reduces body weight gain in mice

T Asagami, JK Belanoff, J Azuma, CM Blasey… - Journal of nutrition and …, 2011 - hindawi.com
Previous research has shown that mifepristone can prevent and reverse weight gain in animals
and human subjects taking antipsychotic medications. This proof-of-concept study tested …

Rosuvastatin attenuates monocyte-endothelial cell interactions and vascular free radical production in hypercholesterolemic mice

W Li, T Asagami, H Matsushita, KH Lee… - Journal of Pharmacology …, 2005 - ASPET
One of the earliest observable events in atherogenesis is enhanced monocyte adhesion to
the endothelium. In addition to reducing circulating levels of cholesterol, 3-hydroxy-3-…