The liver is a heterogeneous organ with many vital functions, including metabolism of
pharmaceutical drugs and is highly susceptible to injury from these substances. The etiology of …

We report here the development and optimization of a simple 384-well colorimetric assay to
measure H 2 O 2 generated by the redox cycling of compounds incubated with reducing …

We have screened the Library of Pharmacologically Active Compounds (LOPAC) and the
National Institutes of Health (NIH) Small Molecule Repository (SMR) libraries in a horseradish …

The development of preclinical models amenable to live animal bioactive compound screening
is an attractive approach to discovering effective pharmacological therapies for disorders …

West Nile virus (WNV), a member of the Flavividae family, is a mosquito-borne, emerging
pathogen. In addition to WNV, the family includes dengue, yellow fever, and Japanese …

Heterogeneity is a fundamental property of biological systems at all scales that must be
addressed in a wide range of biomedical applications, including basic biomedical research, drug …

Although the process of drug development requires efficacy and toxicity testing in animals
prior to human testing, animal models have limited ability to accurately predict human …

High-throughput screening (HTS) has achieved a dominant role in drug discovery over the
past 2 decades. The goal of HTS is to identify active compounds (hits) by screening large …

One of the greatest challenges in biomedical research, drug discovery and diagnostics is
understanding how seemingly identical cells can respond differently to perturbagens including …

Target identification and validation remain difficult steps in the drug discovery process, and
uncovering the core genes and pathways that are fundamental for cancer cell survival may …