A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?

A Hemmerlin, JL Harwood, TJ Bach - Progress in lipid research, 2012 - Elsevier
When compared to other organisms, plants are atypical with respect to isoprenoid biosynthesis:
they utilize two distinct and separately compartmentalized pathways to build up isoprene …

Some new aspects of isoprenoid biosynthesis in plants—a review

TJ Bach - Lipids, 1995 - Wiley Online Library
Plants are capable of synthesizing a myriad of isoprenoids and prenyl lipids. Much attention
has been focused on 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGR), the enzyme that …

The potential of the mevalonate pathway for enhanced isoprenoid production

P Liao, A Hemmerlin, TJ Bach, ML Chye - Biotechnology advances, 2016 - Elsevier
The cytosol-localised mevalonic acid (MVA) pathway delivers the basic isoprene unit
isopentenyl diphosphate (IPP). In higher plants, this central metabolic intermediate is also …

[HTML][HTML] Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells

…, C Grosdemange-Billiard, M Rohmer, TJ Bach - Journal of Biological …, 2003 - ASBMB
In plants, two pathways are utilized for the synthesis of isopentenyl diphosphate, the universal
precursor for isoprenoid biosynthesis. The key enzyme of the cytoplasmic mevalonic acid (…

Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase

LF Wentzinger, TJ Bach, MA Hartmann - Plant Physiology, 2002 - academic.oup.com
To get some insight into the regulatory mechanisms controlling the sterol branch of the
mevalonate pathway, tobacco (Nicotiana tabacum cv Bright Yellow-2) cell suspensions were …

Overexpression of Brassica juncea wild‐type and mutant HMG‐CoA synthase 1 in Arabidopsis up‐regulates genes in sterol biosynthesis and enhances sterol …

…, P Bouvier‐Navé, D Guo, TJ Bach… - Plant biotechnology …, 2012 - Wiley Online Library
Brassica juncea 3‐hydroxy‐3‐methylglutaryl‐CoA synthase (HMGS) is encoded by four
isogenes (BjHMGS1‐BjHMGS4). In vitro enzyme assays had indicated that the recombinant …

Hydroxymethylglutaryl-CoA reductase, a key enzyme in phytosterol synthesis?

TJ Bach - Lipids, 1986 - Springer
Hydroxymethylglutaryl-CoA reductase (HMGR) regulates the synthesis of mevalonic acid (MVA),
the precursor of the myriad of isoprenoid compounds functional in plant cells, with …

Inhibition by mevinolin of plant growth, sterol formation and pigment accumulation

TJ Bach, HK Lichtenthaler - Physiologia plantarum, 1983 - Wiley Online Library
To obtain information on the importance of a functional mevalonate synthesis for plant growth
and development, we investigated the effect of mevinolin, a highly specific inhibitor of 3‐…

Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase

…, A Hemmerlin, A Willem, TJ Bach… - Biochemical …, 2005 - portlandpress.com
Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against
pathogenic bacteria and the malaria parasite Plasmodium falciparum. 4-(Hydroxyamino)-4-…

Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells

A DISCH, A HEMMERLIN, TJ BACH… - Biochemical …, 1998 - portlandpress.com
Study of the incorporation of 13 C-labelled glucose or pyruvate into the isoprenoids of tobacco
BY-2 cells allowed the biosynthetic origin of isopentenyl diphosphate to be determined. …