Perspectives and Advances in the Understanding of Tuberculosis

RL Kinsella, DX Zhu, GA Harrison… - Annual Review of …, 2021 - annualreviews.org
… risk of developing active TB, meaning the person will experience the clinical symptoms … TB.
Seropositive individuals who do not develop active TB are often considered to have latent TB

[HTML][HTML] Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen …

RL Kinsella, JM Kimmey, A Smirnov, R Woodson… - PLoS …, 2023 - journals.plos.org
The immune response to Mycobacterium tuberculosis infection determines tuberculosis
disease outcomes, yet we have an incomplete understanding of what immune factors contribute …

Fatty acid biosynthesis in Mycobacterium tuberculosis: Lateral gene transfer, adaptive evolution, and gene duplication

RJ Kinsella, DA Fitzpatrick… - Proceedings of the …, 2003 - National Acad Sciences
… human pathogens Mycobacterium tuberculosis and Mycobacterium leprae. M. tuberculosis
is a … It is estimated that over the next 25 years, 40 million people will die from tuberculosis (1). …

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis

…, S Sarkar, DX Zhu, RL Kinsella… - Proceedings of the …, 2019 - National Acad Sciences
… in the world, Mycobacterium tuberculosis (Mtb) causes … tuberculosis (TB) (7), leading to
the emergence of drug-resistant mutant strains of Mtb. In 2017, out of the 10 million cases of TB, …

Autophagy promotes efficient T cell responses to restrict high-dose Mycobacterium tuberculosis infection in mice

S Feng, ME McNehlan, RL Kinsella… - Nature …, 2024 - nature.com
… akin to active TB and emphasize an association of heightened IFN signalling with active TB.
… Given the association between heightened macrophage IFN responses and TB disease …

Eukaryotic genes in Mycobacterium tuberculosis? Possible alternative explanations

RJ Kinsella, JO McInerney - Trends in Genetics, 2003 - cell.com
3. Conclusion We believe that it is not sufficient to propose HGT on the basis of E-values
obtained from BLAST hits or on the basis that there are no other bacterial orthologues available. …

Identification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis

…, M Singh, K Jayaraman, LA Weiss, RL Kinsella… - Msphere, 2019 - Am Soc Microbiol
… as tuberculosis, caused by Mycobacterium tuberculosis. Of the 10 million cases of tuberculosis
in … tuberculosis resistant to at least one frontline antibiotic. There is a clear need for new …

Type I IFN signaling mediates NET release to promote Mycobacterium tuberculosis replication and granuloma caseation

CS Chowdhury, RL Kinsella, EM Nehls, SK Naik… - bioRxiv, 2022 - biorxiv.org
Tuberculosis (TB) remains a leading cause of death due to infectious disease. The 1.5 million
TB-… Possible outcomes of pulmonary Mycobacterium tuberculosis (Mtb) infection include …

Thoracoplasty in the Treatment of Pulmonary Tuberculosis, An Analysis of Results Five to Twenty-six Years After Operation

TJ Kinsella, ES Mariette, PM Matill… - … of Tuberculosis, 1949 - atsjournals.org
… , caring for the tuberculous individuals of Hennepin County, … suffering from pulmonary
tuberculosis were admitted to this … , and 693 with minimal tuberculosis. The senior medical and …

[PDF][PDF] BLOOD MEDIA FOR THE CULTIVATION OF MYCOBACTERIUM TUBERCULOSIS VII: Comparison of Blood Agar-Penicillin and Lowenstein-Jensen Media …

MS Tarshis, PC Kinsella, MV Parker - Journal of Bacteriology, 1953 - Am Soc Microbiol
MATERIALS AND METHODS The formulas and the methods of preparing the media are given
below. Blood medium. Agar,'1.5 g; glycerol (analytical grade), 1.0 ml; human bank blood (…