… Nevertheless from adherent LT73 and A549 cell lines we were able to consistently expand
cells growing as floating spheres (A549/s and LT73/s) that allowed a variety of cellular and …

The expression of DNA topoisomerase II α and β genes was studied in murine normal tissues.
Northern blot analysis using probes specific for the two genes showed that the patterns of …

Background Radiotherapy is one of the main treatment options for non-metastatic prostate
cancer (PCa). Although treatment technical optimization has greatly improved local tumor …

Doxorubicin and idarubicin are very effective anticancer drugs in the treatment of human
hematological malignancies and solid tumors. These agents are well known topoisomerase II …

Effective anticancer agents, such as epipodophyllotoxins and anthracyclines, exert their
antitumor activity through stabilization of cleavable topoisomerase II/DNA complexes, which may …

The molecular mechanism of cisplatin uptake remains poorly defined and impaired drug
accumulation may be implicated in the acquisition of resistance to cisplatin. Thus, we used cell …

The design, modeling, synthesis and biological activity evaluation of two hybrid agents formed
by 7-oxyiminomethylcamptothecin derivatives and diaminedichloro-platinum (II) complex …

Drug resistance limits the achievement of persistent cures for the treatment of melanoma, in
spite of the efficacy of the available drugs. The aim of the present study was to explore the …

Reconfiguring the structure and selectivity of existing chemotherapeutics represents an
opportunity for developing novel tumor‐selective drugs. Here, as a proof‐of‐concept, the use of …

This research aims to simulate bio-contamination risk propagation under real-life conditions
in the water distribution system (WDS) of Lille University's Scientific City Campus (France), …