User profiles for S. Nagar

Seema Nagar

IBM Research
Verified email at in.ibm.com
Cited by 3178

Geminiviruses: models for plant DNA replication, transcription, and cell cycle regulation

…, SB Settlage, BM Orozco, S Nagar… - Critical Reviews in …, 1999 - Taylor & Francis
… Similarly, in bromodeoxyuridine (BrdU) incorporation experiments, chromosomal as well
as viral DNA was efficiently labeled by the nucleotide analog (Nagar, Hanley-Bowdoin and …

Hazardous heavy metals contamination of vegetables and food chain: Role of sustainable remediation approaches-A review

…, S Nagar, QV Bach, H Kamyab, SA Khan, S Yadav… - Environmental …, 2019 - Elsevier
This review emphasizes the role of toxic metal remediation approaches due to their broad
sustainability and applicability. The rapid developmental processes can incorporate a large …

Geminiviruses: models for plant DNA replication, transcription, and cell cycle regulation.

…, SB Settlage, BM Orozco, S Nagar… - Critical Reviews in …, 2000 - europepmc.org
Geminiviruses have small, single-stranded DNA genomes that replicate through double-stranded
intermediates in the nuclei of infected plant cells. Viral double-stranded DNA also …

AI Fairness 360: An extensible toolkit for detecting and mitigating algorithmic bias

…, S Mehta, A Mojsilović, S Nagar… - IBM Journal of …, 2019 - ieeexplore.ieee.org
… We used Python’s Flask framework for building the service and exposed a REST API that …
, but it can be expanded to support the user’s own data upload. The service is also limited to …

[HTML][HTML] Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription

…, MW Akhtar, J Parker, F Soldner, CR Sunico, S Nagar… - Cell, 2013 - cell.com
Parkinson's disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the
substantia nigra pars compacta (SNpc). An association has been reported between PD and …

Origin and differentiation of human memory CD8 T cells after vaccination

…, G Alexe, S Nagar, MM McCausland, S Gupta… - Nature, 2017 - nature.com
The differentiation of human memory CD8 T cells is not well understood. Here we address
this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity in …

Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials

…, J Xu, A Beck, R Fineman, S Heeke, J Winter, S Nagar… - The Lancet, 2018 - thelancet.com
Background The Zika virus epidemic and associated congenital infections have prompted
rapid vaccine development. We assessed two new DNA vaccines expressing premembrane …

Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver

…, Y Lai, P Matsson, A Moss, S Nagar… - Clinical …, 2013 - Wiley Online Library
Intracellular concentrations of drugs and metabolites are often important determinants of
efficacy, toxicity, and drug interactions. Hepatic drug distribution can be affected by many factors…

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport‐mediated PK and DDIs in humans

…, M Jamei, JC Kalvass, S Nagar… - Clinical …, 2013 - Wiley Online Library
This white paper provides a critical analysis of methods for estimating transporter kinetics
and recommendations on proper parameter calculation in various experimental systems. …

Herb–drug interactions: challenges and opportunities for improved predictions

SJ Brantley, AA Argikar, YS Lin, S Nagar… - Drug Metabolism and …, 2014 - ASPET
Supported by a usage history that predates written records and the perception that “natural”
ensures safety, herbal products have increasingly been incorporated into Western health …