Offline reinforcement learning: Tutorial, review, and perspectives on open problems
… the learned policy π(a|s) to gather additional states s ∼ dπ(s), and then access optimal action
… If π(a|s) is trained via empirical risk minimization on s ∼ dπ(s) and optimal labels a⋆, and …
… If π(a|s) is trained via empirical risk minimization on s ∼ dπ(s) and optimal labels a⋆, and …
How to train your robot with deep reinforcement learning: lessons we have learned
Deep reinforcement learning (RL) has emerged as a promising approach for autonomously
acquiring complex behaviors from low-level sensor observations. Although a large portion of …
acquiring complex behaviors from low-level sensor observations. Although a large portion of …
Developmental determinants of sensitivity and resistance to stress
S Levine - Psychoneuroendocrinology, 2005 - Elsevier
The purpose of this paper is two fold. First, to revisit the issue of the definition of stress and
to highlight the difficulties with the contemporary definitions and, second, to review the …
to highlight the difficulties with the contemporary definitions and, second, to review the …
[HTML][HTML] Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and
cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional …
cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional …
[HTML][HTML] Core transcriptional regulatory circuitry in human embryonic stem cells
The transcription factors OCT4, SOX2, and NANOG have essential roles in early development
and are required for the propagation of undifferentiated embryonic stem (ES) cells in …
and are required for the propagation of undifferentiated embryonic stem (ES) cells in …
[HTML][HTML] Control of developmental regulators by Polycomb in human embryonic stem cells
Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the Polycomb …
contributions to human development are not well understood. We have mapped the Polycomb …
Polycomb complexes repress developmental regulators in murine embryonic stem cells
…, T Brambrink, LA Medeiros, TI Lee, SS Levine… - nature, 2006 - nature.com
The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the ability
to differentiate into virtually all adult cell types are not well understood. Polycomb group (…
to differentiate into virtually all adult cell types are not well understood. Polycomb group (…
Mediator and cohesin connect gene expression and chromatin architecture
…, CC Ebmeier, J Goossens, PB Rahl, SS Levine… - Nature, 2010 - nature.com
Transcription factors control cell-specific gene expression programs through interactions
with diverse coactivators and the transcription apparatus. Gene activation may involve DNA …
with diverse coactivators and the transcription apparatus. Gene activation may involve DNA …
[HTML][HTML] A chromatin landmark and transcription initiation at most promoters in human cells
We describe the results of a genome-wide analysis of human cells that suggests that most
protein-coding genes, including most genes thought to be transcriptionally inactive, …
protein-coding genes, including most genes thought to be transcriptionally inactive, …
Trust region policy optimization
In this article, we describe a method for optimizing control policies, with guaranteed monotonic
improvement. By making several approximations to the theoretically-justified scheme, we …
improvement. By making several approximations to the theoretically-justified scheme, we …