We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

… During DNA replication, S 6 -methylthioguanine mispairs with thymine or cytosine, and the
… blotting kit, according to the manufacturer’s instructions, except that the second antibody (…

… DNA damage-induced checkpoints act at the G 1 -S phase transition, during the S phase,
and at the G 2 -M boundary. The serine/threonine protein kinases ATM (ataxia-telangiectasia …

… by AS/S cells and its expression was maximal when AS/S cells approached … S cells close
to replicative senescence showed a dramatic decrease of telomerase activity (Fig. 8 E, AS/S…

The action of Lonidamine [1-(2,4-dichlorobenzyl)-1-H-indazol-3-carboxylic acid] on oxygen
consumption and the rate of aerobic and anaerobic lactate production by Ehrlich ascites …

The vascular endothelial growth factor is produced by a large variety of human tumors,
including melanoma, in which it appears to play an important role in the process of tumor-induced …

The use of IFN-α in clinical oncology has generally been based on the rationale of exploiting
its antiproliferative and antiangiogenic activities. However, IFN-α also exhibits enhancing …

… Antibodies listed below were used in accordance to the manufacturer’s instructions: Mouse
monoclonal antibody to Alix (3A9 #MA183977, Thermo Scientific, Waltham, MA USA); Mouse …

… P < 0.01 according to Student’s t-test comparing mRNA levels determined using primers
for … P < 0.01 according to paired Student’s t-test comparing SKI mRNA levels of miR-155/prec-…

Altered expression of microRNAs (miRNAs) has been detected in cancer, suggesting that
these small non-coding RNAs can act as oncogenes or tumor suppressor genes. In the …