… Shown is the patient’s second response after she had … to 250 mg twice daily once the patient’s
liver-function tests showed … and led to the patient’s relapse. Lorlatinib was effective against …

Despite abundant evidence that aberrant Rho-family GTPase activation contributes to most
steps of cancer initiation and progression, there is a dearth of inhibitors of their effectors (eg, …

… In summary, the shape complementarity of dinaciclib in pCDK2′s ATP binding pocket,
along with the unique hinge sequence of CDK2, provide a structural rationale for the high …

… Factors involved in choosing the appropriate antibiotic(s) include infection type, infecting …
Once the infecting organism(s) is isolated and sensitivities are established, the initial antibiotic(s…

… 10 5 –10 7 M −1 s −1 ), despite their low specific reactivity (k inact ≤ 2.1 × 10 −3 s −1 ),
which is … One reversible interaction is between EGFR-Cys 797 nucleophile and the inhibitor’s …

4-1BB (CD137, TNFRSF9) is a costimulatory receptor expressed on several subsets of
activated immune cells. Numerous studies of mouse and human T cells indicate that 4-1BB …

… Subsequent binding of substrate would then trap the E$S$I complex. This could explain the
… $S complex is slow relative to both the formation of the E$I complex and turnover of the E$S …

Psoriasis is clinically a heterogeneous disease. Detailed evaluation of phenotype at disease
onset is lacking. This study is a baseline characterization of 400 adult individuals with first …

Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1) plays an
important role in vascular development, remodeling, and pathologic angiogenesis. Here we …

… in the ‘S’ domain, and that the mole fraction of the ‘S’ conformers for the purines is high (>
90%). Similar results were obtained with the other triplexes (data not shown). This information, …