… Minimal essential medium (MEM) containing Earle’s salts, penicillin and streptomycin
were from Life Technologies Inc. (Gaithersburg, Md.); fetal calf serum was from Biochrom KG (…

The expression of CD62 on the surface of platelets is considered to be an indicator of platelet
degranulation and secretion. We characterized the relationship between CD62 expression …

Vascular endothelial growth factor (VEGF) has been implicated in the reendothelialization
of the vascular wall after balloon injury. This study investigated whether thrombin, which is …

This review summarizes scientific, ethical and regulatory aspects of Phase I clinical trials
with monoclonal antibodies. The current standard requirements for preclinical testing and for …

… Statistical analyses were performed with the use of the Student’s paired t test (two-tailed)
or an ANOVA followed by Fisher’s protected least significant difference test to identify …

… In brief, sample (100 µl) was added to a TruCount tube, followed by 400 µl of LeucoCount
reagent and then gently vortexed for <15 s. Tubes were left in the dark for at least 5 min and …

FVIII therapy for haemophilia A is safe and effective, with the problem of individually sufficient
efficacy unsettled. Routine one-stage clotting assays and tests employing chromogenic …

Background: The beneficial effect of moderate alcohol consumption in lowering the risk of
cardiovascular disease has been shown in several epidemiologic studies. Such studies have …

… Statistical analyses were performed with a Student’s paired t test (2-tailed) or an ANOVA
followed by Fisher’s protected least significant difference test to compare 2 treatments. A value …

Although the administration of recombinant coagulation factor VIIa (rFVIIa) is a well established
treatment in haemophilia with inhibitory antibodies, monitoring the therapeutic efficacy is …