… Cverexpression studies demonstrate that Bax and Bak can kill the same cells but this may
not be relevant as far as normal cells and apoptotic stimuli are concerned (SN Farrow and R …

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals
that they need to interpret and translate into an appropriate response to their environment. …

Diurnal variation in inflammatory and immune function is evident in the physiology and
pathology of humans and animals, but molecular mechanisms and mediating cell types that …

A NUMBER of DNA viruses carry apoptosis-inhibiting genes which enable the virus to
escape from the host reponse 1–5 . The adenovirus E1B 19K protein can inhibit apoptosis …

During beneficial inflammation, potentially tissue-damaging granulocytes undergo apoptosis
before being cleared by phagocytes in a non-phlogistic manner. Here we show that the rate …

THE cell-killing effects of the cytokines TNF-α and FasL are mediated by the distinct cell-surface
receptors TNFR1, TNFR2 and Fas (also known as CD95/APO-1), which are all members …

Diseases of failed inflammation resolution are common and largely incurable. Therapeutic
induction of inflammation resolution is an attractive strategy to bring about healing without …

Activation of the innate immune system plays a key role in exacerbations of chronic lung
disease, yet the potential role of lung fibroblasts in innate immunity and the identity of epithelial …

Fluticasone furoate (FF) is a novel enhanced-affinity glucocorticoid that has been developed
as topical therapy for allergic rhinitis. The pharmacological properties of FF have been …

Tumor necrosis factor (TNF) apoptosis-inducing ligand (TRAIL), a member of the TNF family,
induces apoptosis in many transformed cells. We report TRAIL-induced NF-κB activation, …