The comparison of machine learning and mechanistic in vitro–in vivo extrapolation models for the prediction of human intrinsic clearance

…, L Di, NA Woody, DA Tess, SM Osgood… - Molecular …, 2023 - ACS Publications
Accurate prediction of human pharmacokinetics (PK) remains one of the key objectives of
drug metabolism and PK (DMPK) scientists in drug discovery projects. This is typically …

Enhancing ketamine translational pharmacology via receptor occupancy normalization

CL Shaffer, SM Osgood, DL Smith, JH Liu, PE Trapa - Neuropharmacology, 2014 - Elsevier
Ketamine is used preclinically and clinically to study schizophrenia and depression.
Accordingly, it is imperative to understand the temporal relationship between the central …

Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574

CL Shaffer, RS Hurst, RJ Scialis, SM Osgood… - … of Pharmacology and …, 2013 - ASPET
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) positive allosteric
modulation (ie, “potentiation”) has been proposed to overcome cognitive impairments in …

Prediction of human brain penetration of P-glycoprotein and breast cancer resistance protein substrates using in vitro transporter studies and animal models

B Feng, AC Doran, L Di, MA West, SM Osgood… - Journal of …, 2018 - Elsevier
Four P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) substrates with
human cerebrospinal fluid (CSF) concentrations and preclinical neuropharmacokinetics were …

Use of PCR for detection of subpatent infections of lizard malaria: implications for epizootiology

SL Perkins, SM Osgood, JJ Schall - Molecular Ecology, 1998 - Wiley Online Library
The estimated prevalence of a malaria parasite, Plasmodium mexicanum, of western fence
lizards, Sceloporus occidentalis, was compared using two techniques: microscopic …

[HTML][HTML] Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy

…, L Barnhart, SM Osgood, Y Belkaid, SM Holland… - JCI insight, 2020 - ncbi.nlm.nih.gov
Abstract Changes in maternal immunity during pregnancy can result in an altered immune
state, and as a natural perturbation, this provides an opportunity to understand functional …

An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations

AC Doran, SM Osgood, JY Mancuso… - Drug metabolism and …, 2012 - ASPET
Previous publications suggest that interstitial fluid compound concentrations (C ISF ) best
determine quantitative neurotherapeutic pharmacology relationships, although confirming …

The Discovery and Characterization of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl) …

…, L Xie, K Karki, DK Bryce, SM Osgood… - Journal of Medicinal …, 2015 - ACS Publications
A unique tetrahydrofuran ether class of highly potent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid receptor potentiators has been identified using rational and structure-based …

[BOOK][B] French royalism under the Third and Fourth Republics

SM Osgood - 2012 - books.google.com
" Let them come forward, they are thirsty for the sight of a King," said Henri IV to his followers
who were trying to push back the curious crowds as he entered Paris in February, I594. It is …

[PDF][PDF] Compact isospectral sets of surfaces

B Osgood, R Phillips, P Sarnak - Journal of functional analysis, 1988 - core.ac.uk
In this paper we study sets of surfaces which are isospectral with respect to the Laplace-Beltrami
operator. More specifically, for closed surfaces (compact, no boundary) we consider a …