Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Use of metal carbonyl-based compounds capable of releasing carbon monoxide (CO) in
biological systems have emerged as a potential adjunctive therapy for sepsis via their …

Objectives : The purpose of this study was to test whether mitochondrial dysfunction is
causative of sepsis sequelae, a mouse model of peritonitis sepsis induced by cecal ligation and …

Mutations of LRRK2, encoding leucine-rich repeat kinase 2 (LRRK2), are the leading cause
of autosomal dominant Parkinson’s disease (PD). The most frequent of these mutations, …

Neuroinflammation and mitochondrial dysfunction, key mechanisms in the pathogenesis of
Parkinson's disease (PD), are usually explored independently. Loss‐of‐function mutations of …

Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell
culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and …

Lamellarin D (Lam D), a marine alkaloid, exhibits a potent cytotoxicity against many different
tumors. The pro-apoptotic function of Lam D has been attributed to its direct induction of …

Objective: Growing evidence suggests that mitochondria function is impaired in sepsis. Here,
we tested the hypothesis that lipopolysaccharide would induce mitochondrial Ca 2+ …

We tested whether inhibition of mitochondrial membrane potential dissipation by CsA (ciclosporin
A) would prevent doxorubicin-induced myocardial and mitochondrial dysfunction. …

INTRODUCTION: Ischemic postconditioning (IpostC) has been described in both heart and
brain. The first aim of this study was to evaluate the effects of IpostC on brain infarct size and …