Heart failure is the major cause of hospitalization, morbidity and mortality worldwide. Previous
experimental and clinical studies have suggested that there is an increased production of …

Vascular smooth muscle (VSM) derived from pulmonary arteries generally contract to
hypoxia, whereas VSM from systemic arteries usually relax, indicating the presence of basic …

… Reprinted with permission from Gupte et al. (32) with modifications. … Ata H, Rawat DK,
Lincoln T, Gupte SA. Mechanism of glucose-6-phosphate dehydrogenase-mediated regulation of …

Increased oxidative stress is a known cause of cardiac dysfunction in animals and patients
with diabetes, but the sources of reactive oxygen species [eg, superoxide anion (O 2 − )] and …

… This study was supported by an AHA Scientist Development grant (SA Gupte), and by HL-31069
and HL-66331 (MSW), and P01 HL-74237 (FA Recchia). Authors would like to thank Dr. …

… Address for reprint requests and other correspondence: SA Gupte, Dept. of Pharmacology
and Center for Pulmonary Hypertension, New York Medical College, 15 Dana Rd., Valhalla, …

Oxidant production and regulation is becoming increasingly important in the study of vascular
signaling mechanisms, and recent reviews have characterized some of the possible roles …

Pulmonary arterial hypertension (PAH) is a debilitating and deadly disease with no known
cure. Heart failure is a major comorbidity and a common cause of the premature death of …

Glucose metabolism through the glycolysis and hexosamine pathway has been shown to
be altered in type 2 diabetes. However, the fate of glucose through the pentose phosphate …

… Gupte and Oka originally reported that G6PD and G6PD-derived NADPH mediate hypoxic
pulmonary vasoconstriction (76) and hypoxia-induced contraction of bovine and rat PA (31, 73…