Mechanism of action of antipsychotic drugs: from dopamine D2 receptor antagonism to glutamate NMDA facilitation
M Laruelle, WG Frankle, R Narendran, LS Kegeles… - Clinical …, 2005 - Elsevier
BACKGROUND:: The fundamental pathologic processes associated with schizophrenia
remain uncertain. OBJECTIVE:: The goal of this article was to review imaging evidence …
remain uncertain. OBJECTIVE:: The goal of this article was to review imaging evidence …
Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study
…, R Narendran, R Gil, E Hackett, R Girgis… - JAMA …, 2015 - jamanetwork.com
Importance Multiple lines of evidence suggest a deficit in dopamine release in the prefrontal
cortex (PFC) in schizophrenia. Despite the prevalence of the concept of prefrontal cortical …
cortex (PFC) in schizophrenia. Despite the prevalence of the concept of prefrontal cortical …
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
D Martinez, R Narendran, RW Foltin… - American Journal of …, 2007 - Am Psychiatric Assoc
… A significant negative relationship was observed between ΔV 3 ′′ and the choice for 6
mg cocaine in the ventral striatum (r=–0.55, p=0.007), postcommissural putamen (r=–0.45, p=…
mg cocaine in the ventral striatum (r=–0.55, p=0.007), postcommissural putamen (r=–0.45, p=…
Cocaine abuse and sensitization of striatal dopamine transmission: a critical review of the preclinical and clinical imaging literature
R Narendran, D Martinez - Synapse, 2008 - Wiley Online Library
Much effort has been devoted in the preclinical addiction literature to understanding the
phenomenon of sensitization, an enhanced dopaminergic response in the nucleus accumbens …
phenomenon of sensitization, an enhanced dopaminergic response in the nucleus accumbens …
Altered prefrontal dopaminergic function in chronic recreational ketamine users
R Narendran, WG Frankle, R Keefe… - American Journal of …, 2005 - Am Psychiatric Assoc
… Standard curves were linear throughout the range with r 2 >0.99+. Interassay coefficient
of … use (r 2 <0.01, p=0.77) nor with the average hair ketamine concentration (r 2 <0.01, p=0.87). …
of … use (r 2 <0.01, p=0.77) nor with the average hair ketamine concentration (r 2 <0.01, p=0.87). …
Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers
D Martinez, D Orlowska, R Narendran, M Slifstein… - Biological …, 2010 - Elsevier
… Rajesh Narendran has received contracts for scientific work from GlaxoSmithKline. Mark
Slifstein has received compensation for professional services from GlaxoSmithKline and Amgen…
Slifstein has received compensation for professional services from GlaxoSmithKline and Amgen…
Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]‐(+)‐PHNO is a D3 receptor preferring agonist in vivo
R Narendran, M Slifstein, O Guillin, Y Hwang… - Synapse, 2006 - Wiley Online Library
[ 11 C]PHNO is a recently introduced agonist to image DA D 2 ‐like receptors with Positron
Emission Tomography (PET). In cats and humans, [ 11 C]PHNO revealed an atypical …
Emission Tomography (PET). In cats and humans, [ 11 C]PHNO revealed an atypical …
[HTML][HTML] Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
…, VS Peche, A Kluzak, T Shew, R Narendran… - Nature …, 2021 - nature.com
Disruption of lymphatic lipid transport is linked to obesity and type 2 diabetes (T2D), but
regulation of lymphatic vessel function and its link to disease remain unclear. Here we show that …
regulation of lymphatic vessel function and its link to disease remain unclear. Here we show that …
Lower Level of Endogenous Dopamine in Patients With Cocaine Dependence: Findings From PET Imaging of D 2 /D 3 Receptors Following …
…, A Broft, D Kumar, F Liu, R Narendran… - American Journal of …, 2009 - Am Psychiatric Assoc
… (r=0.64, p=0.01 [ Figure 2 ]) and AMPT (r=0.54, p=0.04) conditions. No relationship was
seen between percent change in nondisplaceable binding potential and cocaine use, and no …
seen between percent change in nondisplaceable binding potential and cocaine use, and no …
Increased prefrontal cortical D1 receptors in drug naïve patients with schizophrenia: a PET study with [11C]NNC112
…, LS Kegeles, N Urban, R Narendran… - Journal of …, 2012 - journals.sagepub.com
… Xiaoyan Xu, Judy Thompson and Nina Urban, have no potential conflicts of interest, Roberto
Gil has received research support from Pfizer, Raj Narendran received grant support from …
Gil has received research support from Pfizer, Raj Narendran received grant support from …