Mechanism of action of antipsychotic drugs: from dopamine D2 receptor antagonism to glutamate NMDA facilitation

M Laruelle, WG Frankle, R Narendran, LS Kegeles… - Clinical …, 2005 - Elsevier
BACKGROUND:: The fundamental pathologic processes associated with schizophrenia
remain uncertain. OBJECTIVE:: The goal of this article was to review imaging evidence …

Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study

…, R Narendran, R Gil, E Hackett, R Girgis… - JAMA …, 2015 - jamanetwork.com
Importance Multiple lines of evidence suggest a deficit in dopamine release in the prefrontal
cortex (PFC) in schizophrenia. Despite the prevalence of the concept of prefrontal cortical …

Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine

D Martinez, R Narendran, RW Foltin… - American Journal of …, 2007 - Am Psychiatric Assoc
… A significant negative relationship was observed between ΔV 3 ′′ and the choice for 6
mg cocaine in the ventral striatum (r=–0.55, p=0.007), postcommissural putamen (r=–0.45, p=…

Cocaine abuse and sensitization of striatal dopamine transmission: a critical review of the preclinical and clinical imaging literature

R Narendran, D Martinez - Synapse, 2008 - Wiley Online Library
Much effort has been devoted in the preclinical addiction literature to understanding the
phenomenon of sensitization, an enhanced dopaminergic response in the nucleus accumbens …

Altered prefrontal dopaminergic function in chronic recreational ketamine users

R Narendran, WG Frankle, R Keefe… - American Journal of …, 2005 - Am Psychiatric Assoc
… Standard curves were linear throughout the range with r 2 >0.99+. Interassay coefficient
of … use (r 2 <0.01, p=0.77) nor with the average hair ketamine concentration (r 2 <0.01, p=0.87). …

Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers

D Martinez, D Orlowska, R Narendran, M Slifstein… - Biological …, 2010 - Elsevier
… Rajesh Narendran has received contracts for scientific work from GlaxoSmithKline. Mark
Slifstein has received compensation for professional services from GlaxoSmithKline and Amgen…

Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]‐(+)‐PHNO is a D3 receptor preferring agonist in vivo

R Narendran, M Slifstein, O Guillin, Y Hwang… - Synapse, 2006 - Wiley Online Library
[ 11 C]PHNO is a recently introduced agonist to image DA D 2 ‐like receptors with Positron
Emission Tomography (PET). In cats and humans, [ 11 C]PHNO revealed an atypical …

[HTML][HTML] Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells

…, VS Peche, A Kluzak, T Shew, R Narendran… - Nature …, 2021 - nature.com
Disruption of lymphatic lipid transport is linked to obesity and type 2 diabetes (T2D), but
regulation of lymphatic vessel function and its link to disease remain unclear. Here we show that …

Lower Level of Endogenous Dopamine in Patients With Cocaine Dependence: Findings From PET Imaging of D 2 /D 3 Receptors Following …

…, A Broft, D Kumar, F Liu, R Narendran… - American Journal of …, 2009 - Am Psychiatric Assoc
… (r=0.64, p=0.01 [ Figure 2 ]) and AMPT (r=0.54, p=0.04) conditions. No relationship was
seen between percent change in nondisplaceable binding potential and cocaine use, and no …

Increased prefrontal cortical D1 receptors in drug naïve patients with schizophrenia: a PET study with [11C]NNC112

…, LS Kegeles, N Urban, R Narendran… - Journal of …, 2012 - journals.sagepub.com
… Xiaoyan Xu, Judy Thompson and Nina Urban, have no potential conflicts of interest, Roberto
Gil has received research support from Pfizer, Raj Narendran received grant support from …