Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy
MA Atkinson, NK Maclaren, R Luchetta - Diabetes, 1990 - Am Diabetes Assoc
Intensive insulin therapy in patients with recently diagnosed insulin-dependent diabetes
mellitus (IDDM) has been reported to result in a prolonged increase in endogenous insulin-…
mellitus (IDDM) has been reported to result in a prolonged increase in endogenous insulin-…
Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.
…, YH Song, J Cornelius, R Luchetta… - The Journal of …, 1995 - Am Soc Clin Investig
We reported previously that daily injections of isophane insulin prevented both hyperglycemia
and insulitis in nonobese diabetic (NOD) mice (Atkinson, M., N. Maclaren; and R. Luchetta…
and insulitis in nonobese diabetic (NOD) mice (Atkinson, M., N. Maclaren; and R. Luchetta…
Antiproliferative properties of polyamine analogs: a structure-activity study
…, Y Feng, WR Weimar, GR Luchetta… - Journal of medicinal …, 1994 - ACS Publications
A basis set of polyamine analogues was designed and synthesized. These compounds were
used to initiate a systematic investigation of the role of chain length, terminal nitrogen alkyl …
used to initiate a systematic investigation of the role of chain length, terminal nitrogen alkyl …
[PDF][PDF] Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.
…, OG Simell, AB Peck, J Cornelius, R Luchetta… - … of Pharmacology and …, 1996 - Citeseer
In vitro studies suggest that intra-islet nitric oxide production may contribute to the pathogenesis
of autoimmune insulindependent diabetes mellitus. We tested whether aminoguani-dine …
of autoimmune insulindependent diabetes mellitus. We tested whether aminoguani-dine …
The role of charge in polyamine analog recognition
…, F Gao, Q Wu, J Ortiz-Ocasio, GR Luchetta… - Journal of medicinal …, 1995 - ACS Publications
A series of analogues and homologues of iV1/V12-diethylspermine (DESPM) was synthesized,
and their biological properties were evaluated. These tetraamines include a simple …
and their biological properties were evaluated. These tetraamines include a simple …
DRAQ5‐based DNA content analysis of hematolymphoid cell subpopulations discriminated by surface antigens and light scatter properties
…, KP Ahrens, GR Luchetta… - Cytometry Part B …, 2004 - Wiley Online Library
Background Analysis of cell cycle kinetics offers important information regarding the behavior
of normal and neoplastic cells. Most often, cell cycle determinations by flow cytometry (FCM…
of normal and neoplastic cells. Most often, cell cycle determinations by flow cytometry (FCM…
Bisphenol A exposure impairs epididymal development during the peripubertal period of rats: inflammatory profile and tissue changes
…, L de Oliveira Mendes, NR Luchetta… - Basic & Clinical …, 2018 - Wiley Online Library
Bisphenol A (BPA) is a synthetic non‐steroidal oestrogen used in the production of plastics.
BPA can cause alterations in the endocrine system of human beings and animals at varied …
BPA can cause alterations in the endocrine system of human beings and animals at varied …
Immunogenetic Analysis of β-Cell Autoimmunity in NOD Mice: Relationship of Insulitis to T-Lymphocyte—Receptor βnod and Aβnod Genes
…, K Shimpo, M Obata, K Yamada, R Luchetta - Diabetes, 1990 - Am Diabetes Assoc
An early molecular event in the evolution of insulindependent diabetes in humans and NOD
mice appears to involve the interaction of MHC class II molecules, β-cell autoantigen-…
mice appears to involve the interaction of MHC class II molecules, β-cell autoantigen-…
Pertussigen treatment retards, but fails to prevent, the development of type I, insulin-dependent diabetes mellitus (IDDM) in NOD mice
SW Huang, R Luchetta, AB Peck - Autoimmunity, 1991 - Taylor & Francis
Current evidence supports an autoimmune etiopathogenesis for Type I, insulin-dependent
diabetes mellitus (IDDM) in which the pancreatic beta (β)cell is the specific target tissue. …
diabetes mellitus (IDDM) in which the pancreatic beta (β)cell is the specific target tissue. …
A systematic review found that deviations from intention-to-treat are common in randomized trials and systematic reviews
…, P Eusebi, R De Florio, ML Luchetta… - Journal of clinical …, 2017 - Elsevier
Objectives To describe the characteristics, and estimate the incidence, of trials included in
systematic reviews deviating from the intention-to-treat (ITT) principle. Study Design and …
systematic reviews deviating from the intention-to-treat (ITT) principle. Study Design and …