Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy

MA Atkinson, NK Maclaren, R Luchetta - Diabetes, 1990 - Am Diabetes Assoc
Intensive insulin therapy in patients with recently diagnosed insulin-dependent diabetes
mellitus (IDDM) has been reported to result in a prolonged increase in endogenous insulin-…

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

…, YH Song, J Cornelius, R Luchetta… - The Journal of …, 1995 - Am Soc Clin Investig
We reported previously that daily injections of isophane insulin prevented both hyperglycemia
and insulitis in nonobese diabetic (NOD) mice (Atkinson, M., N. Maclaren; and R. Luchetta

Antiproliferative properties of polyamine analogs: a structure-activity study

…, Y Feng, WR Weimar, GR Luchetta… - Journal of medicinal …, 1994 - ACS Publications
A basis set of polyamine analogues was designed and synthesized. These compounds were
used to initiate a systematic investigation of the role of chain length, terminal nitrogen alkyl …

[PDF][PDF] Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.

…, OG Simell, AB Peck, J Cornelius, R Luchetta… - … of Pharmacology and …, 1996 - Citeseer
In vitro studies suggest that intra-islet nitric oxide production may contribute to the pathogenesis
of autoimmune insulindependent diabetes mellitus. We tested whether aminoguani-dine …

The role of charge in polyamine analog recognition

…, F Gao, Q Wu, J Ortiz-Ocasio, GR Luchetta… - Journal of medicinal …, 1995 - ACS Publications
A series of analogues and homologues of iV1/V12-diethylspermine (DESPM) was synthesized,
and their biological properties were evaluated. These tetraamines include a simple …

DRAQ5‐based DNA content analysis of hematolymphoid cell subpopulations discriminated by surface antigens and light scatter properties

…, KP Ahrens, GR Luchetta… - Cytometry Part B …, 2004 - Wiley Online Library
Background Analysis of cell cycle kinetics offers important information regarding the behavior
of normal and neoplastic cells. Most often, cell cycle determinations by flow cytometry (FCM…

Bisphenol A exposure impairs epididymal development during the peripubertal period of rats: inflammatory profile and tissue changes

…, L de Oliveira Mendes, NR Luchetta… - Basic & Clinical …, 2018 - Wiley Online Library
Bisphenol A (BPA) is a synthetic non‐steroidal oestrogen used in the production of plastics.
BPA can cause alterations in the endocrine system of human beings and animals at varied …

Immunogenetic Analysis of β-Cell Autoimmunity in NOD Mice: Relationship of Insulitis to T-Lymphocyte—Receptor βnod and Aβnod Genes

…, K Shimpo, M Obata, K Yamada, R Luchetta - Diabetes, 1990 - Am Diabetes Assoc
An early molecular event in the evolution of insulindependent diabetes in humans and NOD
mice appears to involve the interaction of MHC class II molecules, β-cell autoantigen-…

Pertussigen treatment retards, but fails to prevent, the development of type I, insulin-dependent diabetes mellitus (IDDM) in NOD mice

SW Huang, R Luchetta, AB Peck - Autoimmunity, 1991 - Taylor & Francis
Current evidence supports an autoimmune etiopathogenesis for Type I, insulin-dependent
diabetes mellitus (IDDM) in which the pancreatic beta (β)cell is the specific target tissue. …

A systematic review found that deviations from intention-to-treat are common in randomized trials and systematic reviews

…, P Eusebi, R De Florio, ML Luchetta… - Journal of clinical …, 2017 - Elsevier
Objectives To describe the characteristics, and estimate the incidence, of trials included in
systematic reviews deviating from the intention-to-treat (ITT) principle. Study Design and …