Clinical pharmacokinetics and metabolism of chloroquine: focus on recent advancements

J Ducharme, R Farinotti - Clinical pharmacokinetics, 1996 - Springer
… for R(−)-chloroquine. Following separate administration of the individual enantiomers, R(−)-…
exceeded those of the R(−)-forms, pointing to a preferential metabolism of S(+)-chloroquine. …

Clinical pharmacokinetics of zopiclone

C Fernandez, C Martin, F Gimenez, R Farinotti - Clinical pharmacokinetics, 1995 - Springer
… Since no differences have been observed between the renal clearances of R( -)- and S( +)…
levels of the R(-) enantiomer for N-demethyl-zopiclone. The preferential metabolism of R(-)-…

Physiology of chemotherapy-induced emesis and antiemetic therapy: predictive models for evaluation of new compounds

C Veyrat-Follet, R Farinotti, JL Palmer - Drugs, 1997 - Springer
The physiology of emesis has been studied for several hundred years, focusing on the
different centres involved and the mechanics of expulsion. The vomiting centre receives inputs …

Analysis of vancomycin entry into pulmonary lining fluid by bronchoalveolar lavage in critically ill patients

…, JY Fagon, MC Dombret, R Farinotti… - Antimicrobial agents …, 1993 - Am Soc Microbiol
Vancomycin penetration into the fluid lining the epithelial surface of the lower respiratory
tract was studied by performing fiberoptic bronchoscopy with bronchoalveolar lavage on 14 …

A 6‐month prospective survey of cutaneous drug reactions in a hospital setting

…, V Auzerie, E Mahe, R Farinotti… - British Journal of …, 2003 - academic.oup.com
Background Few prospective studies are available on the incidence and analysis of the
characteristics of adverse cutaneous drug reactions in hospital settings. Objectives A 6‐month …

Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study.

F Servin, R Farinotti, JP Haberer, JM Desmonts - Anesthesiology, 1993 - europepmc.org
… increase was correlated to body weight (R = 0.76, 25.4 +/- 6.5 ml.kg-1.min-1, mean +/- SD).
Volume of distribution at steady state was also correlated to body weight (R = 0.61, 1.63 +/- …

Pharmacokinetics and protein binding of propofol in patients with cirrhosis.

…, ID Cockshott, GF Plummer, R Farinotti - …, 1988 - europepmc.org
The pharmacokinetics and protein binding of propofol were studied in ten patients with cirrhosis
and in ten control patients undergoing elective surgery. All patients received 2.5 mg. kg-…

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation

D Projean, B Baune, R Farinotti, JP Flinois… - Drug Metabolism and …, 2003 - ASPET
… coumarin hydroxylase and S-mephenytoin N-demethylase (r = 0.76) and between coumarin
hydroxylase and paclitaxel 6α-hydroxylase (r = 0.63)]. A significant cocorrelation was also …

Effects of diazepam and midazolam on baroreflex control of heart rate and on sympathetic activity in humans

…, R Gauzit, P Lefevre, E Couderc, R Farinotti… - Anesthesia & …, 1986 - journals.lww.com
The effects of induction of anesthesia with diazepam and midazolam on baroreflex control of
heart rate and on plasma levels of catecholamines were investigated in this study. Group 1 …

P-glycoprotein expression of the human placenta during pregnancy

S Gil, R Saura, F Forestier, R Farinotti - Placenta, 2005 - Elsevier
OBJECTIVE: To investigate whether the placental expression of P-glycoprotein shows a
quantitative difference during pregnancy. STUDY DESIGN: Villous tissue was collected from …