User profiles for R. P. Remmel

Rory Remmel

University of Minnesota
Verified email at umn.edu
Cited by 8835

Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors

…, AB Marnett, BC Crews, RP Remmel… - Journal of medicinal …, 2000 - ACS Publications
Recent studies from our laboratory have shown that derivatization of the carboxylate moiety
in substrate analogue inhibitors, such as 5,8,11,14-eicosatetraynoic acid, and in …

Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 …

…, AB Marnett, KR Kozak, RP Remmel… - Proceedings of the …, 2000 - National Acad Sciences
All nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the cyclooxygenase (COX) isozymes
to different extents, which accounts for their anti-inflammatory and analgesic activities and …

Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver.

SL Nyberg, RP Remmel, HJ Mann, MV Peshwa… - Annals of …, 1994 - ncbi.nlm.nih.gov
OBJECTIVE: Metabolic activity of transformed human liver (Hep G2) cells and primary rat
hepatocytes were compared during in vitro application of a gel entrapment bioartificial liver. …

Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer

S Nagar, RP Remmel - Oncogene, 2006 - nature.com
The uridine diphosphoglucuronosyltransferases (UGTs) belong to a superfamily of enzymes
that catalyse the glucuronidation of numerous endobiotics and xenobiotics. Several human …

[PDF][PDF] Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function

…, BP Amiot, H Khan, RP Remmel… - …, 2009 - Wiley Online Library
The culture of primary hepatocytes as spheroids creates an efficient three‐dimensional tissue
construct for hepatic studies in vitro. Spheroids possess structural polarity and functional …

Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10

UA Argikar, RP Remmel - Drug Metabolism and Disposition, 2009 - ASPET
Valproic acid (VPA) is a widely used anticonvulsant that is also approved for mood disorders,
bipolar depression, and migraine. In vivo, valproate is metabolized oxidatively by …

[PDF][PDF] Rapid, large‐scale formation of porcine hepatocyte spheroids in a novel spheroid reservoir bioartificial liver

…, J Hardin, B Amiot, UA Argikar, RP Remmel… - Liver …, 2005 - Wiley Online Library
We have developed a novel bioreactor based on the observation that isolated porcine
hepatocytes rapidly and spontaneously aggregate into spheroids under oscillation conditions. …

[HTML][HTML] Genomewide association study of tacrolimus concentrations in African American kidney transplant recipients identifies multiple CYP3A5 alleles

…, DP Schladt, W Guan, MB Miller, RP Remmel… - American Journal of …, 2016 - Elsevier
We previously reported that tacrolimus (TAC) trough blood concentrations for African
American (AA) kidney allograft recipients were lower than those observed in white patients. …

Concise review of the cytochrome P 450 s and their roles in toxicology

CJ Omiecinski, RP Remmel… - Toxicological Sciences, 1999 - hero.epa.gov
BIOSIS COPYRIGHT: BIOL ABS. RRM JOURNAL ARTICLE MAMMAL HUMAN CYTOCHROME
P450 GENE FAMILY POLYMORPHISM CYTOCHROME P450 ENZYMES SUBSTRATE …

Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy

…, A Karanam, SE Marino, CM Barkley, RP Remmel… - …, 2019 - Wiley Online Library
… She and Rory P Remmel have a royalty agreement for intravenous topiramate with Ligand
Pharmaceuticals. Ilo E Leppik reports grants from the Epilepsy Foundation, National Institutes …