The synthesis and evaluation of some 2'-and 7-amino acidderivatives of taxol (1) are reported.
Reaction of taxol with N-protected amino acids gave 2'-N-protected amino acid esters of …

The Vinca alkaloids differ in their chemotherapeutic effectiveness and their toxicities. To
determine whether differences are due to a differential effect on the assembly of tubulin into …

… For example, in a recent study (WD Singer and RH Himes, unpublished results) it was
found that the order of K, values was vinepidine (VPD) > VCR > vindesine(VDS) > VLB, but the …

… Donoso, JA, Haskins, KM, and Himes, RH Effect of microtubuleassociated proteins on the …
Donoso, JA, and Himes, RH The action of two Vinca alkaloids on B16 melanoma in vitro. …

… Himes), by funds from the University General Research Fund (PR Burton), and through the
… LEE, YC, FE SAMSON, LL HOUSTON, and RH HIMES. 1974. The in vitro polymerization of …

The action of a synthetic antitubulin agent, nocodazole, on tubulin self-assembly, preformed
microtubules, fast axoplasmic transport and axonal ultrastructure was studied. Nocodazole …

… In this respect it is like nocodazole, a synthetic, methyl-benzimidazolyl carbamate (Himes,
RH, unpublished results). This inhibitory effect of rotenone must be considered when rotenone …

We have successfully used mutagenesis to engineer Taxol (paclitaxel) binding activity in
Saccharomyces cerevisiae tubulin. Taxol, a successful antitumor agent, acts by promoting …

… Microtubule protein was prepared from bovine brain by the method of Tiwari and Suprenant
( 7), and MAP-free brain tubulin was purified by the method of Algaier and Himes ( 8). …

Taxol (1) is a highly potent antitumor agent, exertingits mechanism of action by promoting
the assembly of stable microtubules in cells. We are reporting on the first synthesis and …